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57144-06-6

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57144-06-6 Usage

Uses

3-methoxyandrosta-3,5-dien-17-one is an intermediate used in the synthesis of Drospirenone (D689500) from Androstenedione (A637550).

Check Digit Verification of cas no

The CAS Registry Mumber 57144-06-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,1,4 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57144-06:
(7*5)+(6*7)+(5*1)+(4*4)+(3*4)+(2*0)+(1*6)=116
116 % 10 = 6
So 57144-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H28O2/c1-19-10-8-14(22-3)12-13(19)4-5-15-16-6-7-18(21)20(16,2)11-9-17(15)19/h4,12,15-17H,5-11H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1

57144-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (8R,9S,10R,13S,14S)-3-methoxy-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-one

1.2 Other means of identification

Product number -
Other names 3-methoxy-17-oxo-3,5-androstadiene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57144-06-6 SDS

57144-06-6Relevant articles and documents

Synthesis method of alkyl acid testosterone

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Paragraph 0033-0034; 0049-0050, (2020/12/10)

The invention discloses a synthesis method of alkyl acid testosterone, and belongs to the technical field of synthesis and processing of medicines. The method comprises the following steps of: taking4-androstenedione (4AD) as an initial raw material, firstly, carrying out enol ether protection on the keto group at the site 3, and reducing carbonyl at the site 17 into hydroxyl; or taking 4-androstenedione (4AD) as an initial raw material, firstly carrying out enol ether protection on the keto group at the site 3, then reducing carbonyl at the site 17 into hydroxyl, then carrying out hydrolysison the site 3 to obtain testosterone, and carrying out esterification and third-site hydrolysis to obtain the testosterone ester after testosterone third-site ketal protection. According to the method disclosed by the invention, the third site is protected during esterification reaction, the generation of impurities can be reduced, and an esterification reaction solvent is a water-insoluble organic solvent, so that after the reaction is completed, products can be directly extracted in a layered manner, a large amount of water does not need to be added to separate out the products, the amountof wastewater is reduced, the solvent can be recycled, and the process is more suitable for industrial production.

The invention relates to a raw material synthetic stone androstenedione cholic acid (by machine translation)

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Paragraph 0017; 0018, (2019/01/08)

The invention discloses a high-purity stone of cholic acid synthesis method, comprises the following steps: to androstenedione as the starting material, through the 3 bit enol ether protection, wittig reaction, 3 bit vinyl alcohol the ether escapes protection, 17 site side chain addition, 3 bit carbonyl reduction, saponification reaction, seven-step reaction of catalytic hydrogenation to obtain high-purity of target substance. The method of the invention uses cheap and easily obtained androstenedione as raw materials, innovative synthetic lithocholic, simple process route, each step the reaction yield is high, and the cost is low, the large-scale production of stone cholic acid difficult problem, is suitable for industrial production. (by machine translation)

Method for preparing progesterone

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Paragraph 0038-0040, (2017/08/31)

The invention discloses a completely novel process route for preparing progesterone. The route adopts an initial raw material, namely 4-androstenedione (4AD) which is relatively cheap and easy to obtain, is relatively good in reaction independence of different steps, concise in procedure, simple and convenient to operate, applicable to industrial production and high in yield, and the accumulative yield of 5 steps is 55% or greater, or even up to 60%. In the situation that the price of a conventional raw material, namely 16-dehydropregnenolone acetate, soars, the process route has very high production application and economic values, and more importantly, a highly toxic reagent, namely acetone cyanohydrins, which is used in a conventional method, is not used in the method disclosed by the invention, so that the method is both economic and environmentally friendly, and is beneficial to industrial production.

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