61165-82-0

Upstream product

• 66270-97-1 4-(bromomethyl)-phenylacetic acid phenacyl ester 
• 13734-41-3 (tert-butoxycarbonyl)-L-valine 
• 13737-36-5 4-bromophenylacetic acid 
• 622-47-9 4-tolylacetic acid 
• 111610-40-3 (S)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 4-(2-hydroxy-ethyl)-benzyl ester 
• 96044-43-8 4-(2-hydroxyethyl)benzyl bromide 
• 13734-41-3 t-Boc-L-valine 
• 111610-45-8 (S)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 4-(2-oxo-ethyl)-benzyl ester 
• 66402-58-2 4-(Boc-valyl-oxymethyl)-phenylessigsaeure-phenacylester 
• 119549-48-3 (4-Bromomethyl-phenyl)-acetic acid 2-trimethylsilanyl-ethyl ester 
• 129397-87-1 2-tert-Butoxycarbonylamino-3-methyl-butyric acid 4-(2-trimethylsilanyl-ethoxycarbonylmethyl)-benzyl ester 

Downstream Products

• 17195-26-5 H-Leu-Ala-Gly-Val-OH 
• 66271-11-2 Boc-valyl-4-(oxymethyl)-pam-benzol 
• 72-18-4 L-valine 

Relevant academic research and scientific papers

Improved synthesis of preformed Boc-aminoacid-bridging groups for use in solid phase peptide synthesis

Preformed Boc-aminoacid-bridging groups are synthesized by an improved method, using Tmse temporary protection of the starting 4-(halomethyl)phenylacetic acid or bromoacetic acid.

A NEW PREPARATION OF 4-(BOC-AMINOACYLOXYMETHYL)PHENYLACETIC ACIDS FOR SOLID-PHASE PEPTIDE SYNTHESIS

A new preparation of 4-(BOC-aminoacyloxymethyl)phenylacetic acids 1, constisting of an esterification of the corresponding BOC-amino acids 2 with 4-(bromomethyl)phenethyl alcohol 3, followed by a Collins oxidation and an oxidation with sodium chlorite is

Design and Synthesis of Multidetachable Resin Supports for Solid-Phase Peptide Synthesis

A new and unusually versatile class of supports for solid-phase peptide synthesis has been developed.It contains two orthogonally removable ester bonds, allowing the selective cleavage of the individual bonds by a variety of reagents.The synthetic peptide can be obtained in a free or protected form, or with a removable spacer group still attached at the carboxyl terminus.Two such multidetachable resin supports have been developed in which selective cleavage is by acidolysis, photolysis, or nucleophilic cleavage; they are (1) tert-butoxycarbonylaminoacyl-2-propionyl-copoly(styrene-divinylbenzene) resin (Pop-resin) and tert-butoxycarbonylaminoacyl-4--3-nitrobenzamidomethyl-copoly(styrene-divinylbenzene) resin (Pon-resin).The value of these resins was demonstrated by the stepwise synthesis of Leu-enkephalin and angiotensin II.In addition, applications of this class of supports for fragment synthesis were described.The minimization of side reactions associated with peptide anchored to photolabile resins in the ordinary way was demonstrated.