6118-95-2

Upstream product

• 1885-38-7 cinnamic nitrile 
• 100-63-0 phenylhydrazine 
• 15463-91-9 3-bromo-3-phenylpropionic acid 
• 1012335-04-4 2-benzoyl-1,5-diphenylpyrazolidin-3-one 
• 5443-49-2 α-bromocinnamaldehyde 
• 59-88-1 phenylhydrazine hydrochloride 
• 103-26-4 methyl cinnamate 

Downstream Products

• 1012335-18-0 3-phenyl-3-(phenylamino)propanamide 
• 13370-06-4 1,5-diphenyl-3-hydroxy-1H-pyrazole 
• 1310875-55-8 2-(1,5-diphenyl-1H-pyrazol-3-yloxy)-1-(2-thioxothiazolidin-3-yl)ethanone 
• 73457-62-2 2-(1,5-diphenyl-1H-pyrazol-3-yloxy)acetic acid 
• 1338378-31-6 4-bromo-3-ethoxy-1,5-diphenyl-1H-pyrazole 
• 1338378-39-4 C₁₇H₁₅ClN₂O 
• 1338378-27-0 2-(4-chloro-1,5-diphenyl-1H-pyrazol-3-yloxy)-1-(2-thioxothiazolidin-3-yl)ethanone 
• 1338378-10-1 4-chloro-1,5-diphenyl-1H-pyrazol-3-ol 
• 1338378-24-7 2-(4-chloro-1,5-diphenyl-1H-pyrazol-3-yloxy)acetic acid 
• 1036731-14-2 ethyl 2-(4-chloro-1,5-diphenyl-1H-pyrazol-3-yloxy)acetate 
• 1246513-41-6 ethyl 2-(1,5-diphenyl-1H-pyrazol-3-yloxy)acetate 
• 13370-06-4 1,5-diphenyl-4-pyrazolin-3-one 

Relevant academic research and scientific papers

A convenient one-pot synthesis of 1-aryl-substituted 4-iodopyrazol-3-ols via aromatisation and oxidative iodination reactions

A convenient and economical one-pot synthesis of a series of new 1-aryl-substituted 4-iodopyrazole-3-ols from easily available pyrazolidin- 3-ones in the presence of sodium iodide, 30% solution of hydrogen peroxide and a catalytic amount of sulfuric acid in dichloromethane via aromatisation and oxidative iodination reactions are described. This protocol has the advantages of high atom economy, costeffectiveness, short reaction time and environmental friendliness.

NHC-catalyzed regiodivergent syntheses of difunctionalized 3-pyrazolidinones from α-bromoenal and monosubstituted hydrazine

A formal [3 + 2] annulation of α-bromoenal with monosubstituted hydrazine could give 1,5 or 2,5-difunctionalized 3-pyrazolidinone regiodivergently by tuning the structure of the N-Heterocyclic Carbene (NHC) catalyst. Moderate to high yields, mild reaction conditions, good regioselectivity and potential biological significance of the final product have made this protocol attractive for the assembly of 3-pyrazolidinone.

Direct amination of homoenolates catalyzed by N-heterocyclic carbenes

N-Heterocyclic carbenes derived from N-mesityl-N-methyltriazolium salts are effective catalysts for generating homoenolate species from α,β-unsaturated aldehydes. The unique intermediate adds to the electrophilic nitrogen of 1-acyl-2-aryldiazenes, and the