61195-13-9Relevant academic research and scientific papers
Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C-N bond formation
Tian, Xianhai,Song, Lina,Li, Ertong,Wang, Qiang,Yu, Wenquan,Chang, Junbiao
, p. 62194 - 62201 (2015)
A one-pot I2-mediated annulation reaction of substrates containing diamino groups and aldehydes has been developed via oxidative C-N bond formation. This general and environmentally benign synthetic approach provides facile access to a variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines.
Synthesis of 2-(hetero)arylquinazolinones in aqueous media
Tímea, Magyar,Miklós, Ferenc,Lázár, László,Fül?p, Ferenc
, p. 247 - 258 (2018/05/09)
Mechanochemical treatment of N-unsubstituted or N-methyl anthranilamide with benzaldehyde yielded their Schiff bases derivatives which could be easily cyclized to the corresponding 2-phenyl-2,3-dihydroquinazolinones via thermal rearrangement in water. On the basis of the above findings, an eco-friendly method was applied to prepare quinazolin-4(1H)-one derivatives from anthranilamides and a number of (hetero)aryl aldehydes. Heating the aqueous mixture of starting compounds to 90 °C resulted in the products in 81-94% yields. All products precipitated from the reaction mixture and were isolated by simply filtration. No further work-up or purification was necessary.
