61198-18-3Relevant academic research and scientific papers
CARBO- AND HETERO-CYCLIC ANTIBIOTICS AND USE THEREOF
-
Page/Page column 26, (2008/06/13)
The present invention relates to compounds of the formula (1.0); and pharmaceutically acceptable salts of such compounds. The present invention relates to chemical entities containing a nitrofuran or other antibiotic linked to an activity enhancing distal ring system either directly or via an imine group, vinyl group, carbo- or hetero-cyclic chain or ring or a combination of an imine group or a vinyl group and a carbo- or hetero-cyclic chain or ring. Antibiotic activity is obtained, for example, by the nitrofuran moiety, while the remaining structure of the molecule contributes to additional antimicrobial activity and/or extends the antimicrobial spectrum of activity, by facilitating nitroreduction by microorganisms, uptake in target bacteria, and/or intracellular penetration, while also contributing to pharmacological properties (absorption, body distribution, and others).
2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines
-
, (2008/06/13)
2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines and 2-[2-(5-nitro-2-furyl)vinyl]-4-(hydroxyanilino)quinazolines are prepared and used as pesticides and animal growth promotants. These quinazolines also improve the feed efficiency of animals.
