612-01-1

Basic information

• Product Name: 1-methyl-1,3-diphenylurea
• Synonyms: Urea, N-methyl-N,N'-diphenyl-
• CAS NO: 612-01-1
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.2738
• Mol File: 612-01-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 412.9°C at 760 mmHg
• Flash Point: 203.5°C
• Density: 1.201g/cm³
• Vapor Pressure: 5E-07mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 1-methyl-1,3-diphenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,3-diphenylurea(612-01-1)
• EPA Substance Registry System: 1-methyl-1,3-diphenylurea(612-01-1)

Safety Data

• Hazardous Substances Data: 612-01-1(Hazardous Substances Data)

Usage

Appearance

White, crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Use as a building block

For various organic syntheses

Use as a reagent

Preparation of various organic compounds

Potential biological activities

Antimicrobial, antiviral

Applications

Manufacture of pharmaceuticals, agrochemicals

Ongoing research and development

Yes

Upstream product

• 103-71-9 phenyl isocyanate 
• 100-61-8 N-methylaniline 
• 83-01-2 diphenylcarbamic chloride 
• 5416-30-8 N,N'-diphenyl-S-methyl isothiourea 
• 4960-31-0 Tris(methylphenylamino)methan 
• 102-07-8 bis(diphenyl)urea 
• 103-70-8 Formanilid 
• 18992-89-7 allyl N-phenylcarbamate 
• 121-69-7 N,N-dimethyl-aniline 
• 582-61-6 benzoyl azide 
• 19708-81-7 methyl O-methyldithiocarbonate 
• 62-53-3 aniline 
• 18773-77-8 methyl(phenyl)cyanamide 
• 58109-40-3 diphenyliodonium hexafluorophosphate 

Downstream Products

• 103-71-9 phenyl isocyanate 
• 100-61-8 N-methylaniline 
• 52072-98-7 N-methyl-N,N'-diphenyl-carbamimidoyl chloride 
• 2645-41-2 1-Methyl-1,3,5-triphenyl-biuret 
• 91907-78-7 N-butyl-N-methyl-N'-phenylurea 
• 53463-31-3 N,N-Di-sek.-butyl-N'-phenyl-harnstoff 
• 102899-11-6 N,N-Di-(2-ethyl-hexyl)-N'-phenyl-harnstoff 
• 59849-65-9 N-methyl-N,N'-(diphenyl)propynamidine 
• 93-61-8 N-methyl-N-phenylformamide 
• 121-69-7 N,N-dimethyl-aniline 
• 62-53-3 aniline 
• 23996-36-3 1-methyl-3-phenyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 14813-85-5 1-phenyl-1,3-dihydrobenzoimidazol-2-one 

Relevant articles and documents

Cp2TiCl2-CATALYZED REACTION OF GRIGNARD REAGENTS WITH ISOCYANATES, FORMATION OF REDUCTION-COUPLING PRODUCT OF ISOCYANATES

Phenylisocyanate and phenylthioisocyanate react with Grignard reagents in the presence of a small amount of Cp2TiCl2 at room temperature to afford reduction-coupling products, N-methyl-N,N'-diphenylurea and N-methyl-N,N'-diphenylthiourea.

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

A Novel C–N Migration Rearrangement Based on N–F Compounds for the Synthesis of N-Alkyl Diaryl Ureas

A novel rearrangement reaction based on the structure of N-fluoro-N-(phenylsulfonyl) benzamides (FPSBA) was developed. In the presence of base, unsymmetrical N-alkyl diaryl ureas were obtained in good yields which were accomplished through secondary alkyl phenylamines initiated 1,2-phenyl-shift migration rearrangement of N-fluoro-N-(phenylsulfonyl) benzamides. The reaction was carried out without using traditional, highly toxic reagents and noble metals. Whereas without rearrangement occurrence for primary phenylamines and aliphatic amines, normal amides and N-(phenylsulfonyl) benzamides were afforded respectively. Nitrene and phenyl isocyanate included process were prevented and a secondary alkyl phenylamine initiated vicinal SN2' reaction occurred. This rearrangement reaction features an interesting reaction mechanism, mild reaction conditions, simple operation, and useful products.