612-18-0

Upstream product

• 1466-88-2 2-nitrocinnamic aldehyde 
• 4295-36-7 2,3-dihydroquinolin-4(1H)-one 
• 91-22-5 quinoline 
• 64-17-5 ethanol 
• 766-77-8 Dimethylphenylsilane 

Downstream Products

• 29724-68-3 1-benzoyl-1,2-dihydroquinoline 
• 13268-54-7 1-tosyl-1, 2-dihydroquinoline 
• 16021-60-6 1-Methyl-1,2-dihydroquinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 91-22-5 quinoline 
• 612-96-4 2-Phenylquinoline 
• 40624-66-6 2-phenyl-1,2-dihydroquinoline 
• 24005-23-0 2-phenyl-1,2,3,4-tetrahydroquinoline 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 1613-37-2 Quinoline N-oxide 
• 17718-19-3 benzyl quinoline-1(2H)-carboxylate 
• 1119238-24-2 (R)-1,2,3,4-tetrahydroquinolin-3-ol 

Relevant academic research and scientific papers

Yeast supported gold nanoparticles: an efficient catalyst for the synthesis of commercially important aryl amines

Candida parapsilosisATCC 7330 supported gold nanoparticles (CpGNP), prepared by a simple and green method can selectively reduce nitroarenes and substituted nitroarenes with different functional groups like halides (-F, -Cl, -Br), olefins, esters and nitriles using sodium borohydride. The product aryl amines which are useful for the preparation of pharmaceuticals, polymers and agrochemicals were obtained in good yields (up to >95%) using CpGNP catalyst under mild conditions. The catalyst showed high recyclability (≥10 cycles) and is a robust free flowing powder, stored and used after eight months without any loss in catalytic activity.

Reduction of quinolines to 1,2,3,4-tetrahydroquinolines with hydrosilane/ethanol catalyzed by TiO2-supported gold nanoparticles under solvent free conditions

Gold nanoparticles supported on TiO2 (1 mol%) catalyze the reduction of a series of functionalized quinolines into 1,2,3,4-tetrahydroquinolines using hydrosilanes/ethanol (hydride/proton) as the reductant system. A typical reaction requires 4 molar equivalents of phenyldimethylsilane (reductant of choice), 4 molar equivalents of ethanol as a reagent and heating to 70 °C under solvent free conditions. The isolated yields are moderate to excellent and in certain cases the reaction rate is exceedingly fast. Mechanistic analysis revealed the stereoselective addition of two hydrides (from hydrosilane) on positions C2 and C4 of the quinoline ring and two protons (from ethanol) on positions C3 and the nitrogen atom.