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Usage

Uses

Used in Chemical Synthesis:
m,m'-Dicarboxybiphenyl is used as a precursor or intermediate in various chemical reactions for the synthesis of certain polymers. Its presence of two carboxyl groups allows for versatile chemical modifications and the formation of different compounds.
Used in Polymer Industry:
m,m'-Dicarboxybiphenyl is used as a monomer in the production of certain polymers. Its dicarboxylic acid structure enables the formation of polymer chains through esterification or condensation reactions, contributing to the development of new materials with specific properties for various applications.

Upstream product

• 914-20-5 [1,1']bianthryl-9,10,9',10'-tetraone 
• 34237-98-4 3,3'-dibromo-[1,1'-biphenyl]-4,4'-diamine 
• 25487-66-5 3-Carboxyphenylboronic acid 

Downstream Products

• 303730-26-9 3,3'-dicarbethoxybiphenyl 
• 53172-64-8 3,3'-dibenzoylbiphenyl 
• 172603-95-1 biphenyl-3,3'-diylbis(phenyldiazomethane) 
• 172603-96-2 3,3'-dibenzoylbiphenyl dihydrazone 
• 1029978-09-3 biphenyl-3,3'-dicarboxylic acid bis(2,5-dioxopyrrolidin-1-yl) ester 
• 1092688-50-0 C₈₀H₄₈B₂N₆O₄ 
• 53172-65-9 [3'-(4-tert-Butyl-benzoyl)-biphenyl-3-yl]-(4-tert-butyl-phenyl)-methanone 
• 1751-97-9 biphenyl-3,3'-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds

Bacterial thiol-disulfide oxidoreductase DsbA is essential for bacterial virulence factor assembly and has been identified as a viable antivirulence target. Herein, we report a structure-based elaboration of a benzofuran hit that bound to the active site groove of Escherichia coli DsbA. Substituted phenyl groups were installed at the 5- and 6-position of the benzofuran using Suzuki-Miyaura coupling. HSQC NMR titration experiments showed dissociation constants of this series in the high μM to low mM range and X-ray crystallography produced three co-structures, showing binding in the hydrophobic groove, comparable with that of the previously reported benzofurans. The 6-(m-methoxy)phenyl analogue (2b), which showed a promising binding pose, was chosen for elaboration from the C-2 position. The 2,6-disubstituted analogues bound to the hydrophobic region of the binding groove and the C-2 groups extended into the more polar, previously un-probed, region of the binding groove. Biochemical analysis of the 2,6-disubsituted analogues showed they inhibited DsbA oxidation activity in vitro. The results indicate the potential to develop the elaborated benzofuran series into a novel class of antivirulence compounds.