6121-80-8Relevant academic research and scientific papers
Synthesis process of natural product Agrimonolide (I) racemate extracted from agrimonia pilosa
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, (2018/12/05)
The invention belongs to the field of chemical synthesis, and particularly relates to a total synthesis method of a natural product 6,8-dyhydroxyl-3-(4'-methoxyphenyl ethyl) isochroman-1-ketone (dl-Agrimonolide (I)) extracted from a plant agrimonia pilosa
Targeting the Hsp90 chaperone: Synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90
Day, James E. H.,Sharp, Swee Y.,Rowlands, Martin G.,Aherne, Wynne,Workman, Paul,Moody, Christopher J.
supporting information; experimental part, p. 2758 - 2763 (2010/07/04)
A series of benzo-macrolactones has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. A new synthesis of these resorcylic acid macrolactone analogues of the natural product radicicol is described in which the key steps are the acylation and ring opening of a homophthalic anhydride to give an isocoumarin, followed by a ring-closing metathesis to form the macrocycle. The methodology has been extended to a novel series of macrolactones incorporating a 1,2,3-triazole ring.
An improved synthesis of resorcylic acid macrolactone inhibitors of Hsp90
Day, James E. H.,Blake, Alexander J.,Moody, Christopher J.
scheme or table, p. 1567 - 1570 (2009/11/30)
A synthesis of resorcylic acid macrolactone analogues of the natural product radicicol is described in which the key steps are the acylation and ring opening of a homophthalic anhydride to give an isocoumarin, followed by a ring-closing metathesis to form
Condensation of Diethyl Acetonedicarboxylate. III. Isolation and Acylation of Diethyl Acetonedicarboxylate-Magnesium Complex
Yamato, Masatoshi,Kusunoki, Youichiro
, p. 1214 - 1220 (2007/10/02)
Diethyl acetonedicarboxylate (DADC)-magnesium complex, (DADC)2Mg (5b), was isolated from the reaction of DADC and MgCl2 with Et3N, or by the removal of coordination water from (DADC)2Mg*2H2O (5a).Compound 5b could be regarded as an intermediate in the sel
