61210-87-5

Basic information

• Product Name: [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide
• Synonyms: [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide
• CAS NO: 61210-87-5
• Molecular Weight: 161.203
• Mol File: 61210-87-5.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide(CAS DataBase Reference)
• NIST Chemistry Reference: [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide(61210-87-5)
• EPA Substance Registry System: [((E)-4-phenylbut-3-en-2-ylidene)amino]hydroxide(61210-87-5)

Safety Data

• Hazardous Substances Data: 61210-87-5(Hazardous Substances Data)

Upstream product

• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 1896-62-4 (E)-benzalacetone 
• 122-57-6 1-Phenylbut-1-en-3-one 

Downstream Products

• 51616-91-2 (2E)-1-methyl-3-phenylprop-2-enylamine 
• 4350-44-1 ethyl 2,6-dimethyl-4-phenylpyridine-3-carboxylate 
• 1350770-23-8 2-isopropyl-3,6-dimethyl-4-phenylpyridine 
• 1350770-15-8 C₁₆H₁₉N 
• 1350770-09-0 3-cyclopropyl-6-methyl-2,4-diphenylpyridine 
• 1350770-10-3 C₂₁H₁₉N 
• 1199525-55-7 methyl 6-methyl-2,4-diphenylnicotinate 
• 1350770-48-7 C₂₀H₁₇NO₂ 
• 1350770-14-7 3,6-dimethyl-4-phenyl-2-(4-(trifluoromethyl)phenyl)pyridine 
• 1350770-22-7 C₂₀H₁₆F₃N 
• 1350770-11-4 6-methyl-2,3,4-triphenylpyridine 
• 1350770-16-9 C₂₆H₃₅NO₂Si 
• 1350770-24-9 2-(((tert-butyldimethylsilyl)oxy)(furan-2-yl)methyl)-6-methyl-4-phenyl-3-propylpyridine 
• 1350770-50-1 C₂₅H₃₁NOSi 

Relevant articles and documents

Palladium(II)-Catalyzed Substituted Pyridine Synthesis from ?±,?-Unsaturated Oxime Ethers via a C-H Alkenylation/Aza-6?-Electrocyclization Approach

An efficient synthetic method for multisubstituted pyridines from β-aryl-substituted α,β-unsaturated oxime ethers and alkenes via Pd-catalyzed C-H activation has been developed. Systematic optimization of catalyst ligands revealed that sterically hindered

Sequential Two-Step Stereoselective Amination of Allylic Alcohols through the Combination of Laccases and Amine Transaminases

A sequential two-step chemoenzymatic methodology for the stereoselective synthesis of (3E)-4-(het)arylbut-3-en-2-amines in a highly selective manner and under mild reaction conditions is described. The approach consists of oxidation of the corresponding racemic alcohol precursors by the use of a catalytic system made up of the laccase from Trametes versicolor and the oxy-radical TEMPO, followed by the asymmetric reductive bio-transamination of the corresponding ketone intermediates. Optimisation of the oxidation reaction, exhaustive amine transaminase screening for the bio-transaminations and the compatibility of the two enzymatic reactions were studied in depth in search of a design of a compatible sequential cascade. This synthetic strategy was successful and the combinations of enzymes displayed a broad substrate scope, with 16 chiral amines being obtained in moderate to good isolated yields (29–75 %) and with excellent enantiomeric excess values (94 to >99 %). Interestingly, both amine enantiomers can be achieved, depending on the selectivity of the amine transaminase employed in the system.

Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions

A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.