61220-69-7

Basic information

• Product Name: Tiopinac
• Synonyms: Tiopinac
• CAS NO: 61220-69-7
• Molecular Formula: C16H12O3S
• Molecular Weight: 284.334
• Mol File: 61220-69-7.mol

Chemical Properties

• Boiling Point: 541.3°C at 760 mmHg
• Flash Point: 281.1°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 1.51E-12mmHg at 25°C
• Refractive Index: 1.674
• PKA: 4.14±0.10(Predicted)
• CAS DataBase Reference: Tiopinac(CAS DataBase Reference)
• NIST Chemistry Reference: Tiopinac(61220-69-7)
• EPA Substance Registry System: Tiopinac(61220-69-7)

Safety Data

• Hazardous Substances Data: 61220-69-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12O3S/c17-15(18)8-10-5-6-13-14(7-10)20-9-11-3-1-2-4-12(11)16(13)19/h1-7H,8-9H2,(H,17,18)

Upstream product

• 64976-83-6 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile 
• 61220-81-3 potassium 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetate 
• 61220-68-6 methyl 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetate 
• 65-85-0 benzoic acid 
• 83794-88-1 3-(2-carboxymethylbenzylthio)benzoic acid 
• 83794-91-6 3-(2-carboxymethylbenzylthio)phenylacetonitrile 
• 83794-89-2 3-(2-carboxymethylbenzylthio)benzyl alcohol 
• 83794-90-5 3-(2-carboxymethylbenzylthio)benzyl bromide 
• 83794-92-7 3-(2-carboxybenzylthio)phenylacetonitrile 
• 83794-94-9 3-(2-carboxybenzylthio)benzyl bromide 
• 83794-87-0 2-(1-hydroxymethyl-3-thiophenylmethyl)benzoic acid 
• 4025-64-3 3-Carboxybenzenesulfonyl chloride 
• 4869-59-4 3-mercapto benzoic acid 
• 83794-86-9 3-mercaptobenzyl alcohol 

Relevant articles and documents

Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use

Compounds of Formula I STR1 wherein R1 is the residue of an antiphlogistically effective carboxylic acid of the formula R1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.

An Alternative Synthesis of Tiopinac

Tiopinac (1) thiepin-3-acetic acid, (1)> has been shown a high degree of antiinflammatory activity and a low incidence of side effects in animals (2).On the basis of results, Tiopinac was chosen for human evaluation in 1978 (2a).

6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile

6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid is prepared from 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile, a novel intermediate, by strong acid or base hydrolysis.

6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-carboxaldehyde

This invention relates to a novel method for the preparation of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid and the novel intermediate 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-carboxaldehyde used in the preparation thereof.

3-(2-Dialkylamino-2-dialkylphosphonylvinyl)-6,11-dihydrodibenzo-[b.e.]-thiepin-11-one

This invention relates to a novel method for the preparation of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid and the novel intermediates 3-(2-dialkylamino-2-dialkylphosphonylvinyl)-6,11-dihydrodibenzo-[b.e.]-thiepin-11-one in the preparation thereof.

6,11-Dihydrodibenzo-thiepin-11-ones, compositions and uses thereof

This invention relates to novel 6,11-dihydrodibenzo-[b.e.]-thiepin-11-ones, methods of preparation, compositions and uses thereof.

6,11-Dihydrodibenzo-thiepin-11-ones, compositions and uses thereof

This invention relates to novel 6,11-dihydrodibenzo[b.e.]-thiepin-11-ones, methods of preparation, compositions and uses thereof.