61248-51-9

Upstream product

• 61247-11-8 ((1R)-1-methyl-cyclohexane-1r,2t-diyl)-di-acetic acid 
• 130082-70-1 (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene 
• 103668-33-3 3-hydroxymethylcyclohexene 
• 74676-00-9 Trimethyl-[1-(2-methylene-cyclohexylmethyl)-vinyloxy]-silane 
• 157944-25-7 1-diazo-3-(1-methylcyclohexyl)propan-2-one 
• 39163-29-6 1,4,5,6,7,7a-hexahydro-inden-2-one 
• 15681-48-8 lithium dimethylcuprate 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 16508-51-3 7a-methyl-1,4,5,6,7,7a-hexahydro-2H-inden-2-one 
• 65898-71-7 2-methyl-2-(2-methyl-2-propenyl)cyclohexanone 
• 583-60-8 2-Methylcyclohexanone 
• 938-06-7 (+-)-4a-methyl-cis-octahydro-naphthalen-2-one 
• 43206-33-3 (+/-)-(1-methyl-cyclohexane-1r,2c-diyl)-di-acetic acid 
• 938-07-8 trans-10-methyldecal-2-one 

Downstream Products

• 22920-01-0 ((1S)-2t-carboxy-2c-methyl-cyclohex-r-yl)-acetic acid 
• 54725-16-5 Δ³⁽¹⁾-8-Methyl-hydrindenon-(2) 
• 22920-01-0 cis-2-methyl-2-carboxy-cyclohexane-1-acetic acid 

Relevant academic research and scientific papers

Construction of trans-Ring-fused Compounds by Radical Cyclization

Enolates derived from bicyclic lactones of type (4) are alkylated with prop-2-ynylic (and allylic) bromides to give products (5) in which the unsaturated alkyl group is syn to the remaining ring-fusion hydrogen; prop-2-ynylic aldehydes can be used instead

Palladium(0)-catalyzed reaction of cyclopropylidenecycloalkanes with carbon dioxide

Cyclopropylidenecycloalkanes, which are highly strained methylenecyclopropane (MCPs) containing a cycloalkane moiety, react with carbon dioxide smoothly to give the corresponding five-membered lactone derivatives in moderate to good yields through a cyclo

A synthetic approach to perhydro-3-isoquinolinones bearing an angular methyl group via organocuprate addition

The addition of organocuprates to the activated C-C double bond in 2H-3,3a,4,5,6,7-hexahydro-2-indenone followed by trapping of the anionic intermediate with Mel as electrophile is reported. Structural assignment of the resulting product was carried out v

63. Enantioselective Formation of Bicyclic Lactones by Rhodium-Catalyzed Intramolecular CH-Insertion Reactions

The decomposition of cyclohexyl diazoacetate (5a) in the presence of the chiral 4> catalyst leads to a 3:1 cis/trans mixture of bicyclic lactone 6a with an enantiomeric excess of 95-97percent (cis) and 90percent (trans).The conformationally rigid tert-butyl derivatives 5b and 5c afford, in the presence of the same catalyst, 6b and 6c, respectively, via insertion into the equatorial C-H bonds exclusively, with ee's of ca. 95percent.A remarkable degree of induction (92-95percent) results in the lactone 6g upon decomposition of 1-isopropyl-2-methylpropyl diazoacetate (5g).The diazoacetates derived from 1-methylcyclohexanol, cyclopentanol and 1-methylcyclopentanol (5d-f) afford under similar conditions insertion products with higher diastereoselectivity, but significantly lower enantioselectivity.Other dirhodium catalysts are less efficient.

A Radical Cyclisation Strategy to α-Spiro-β-methylene-γ-butyrolactones. Total Synthesis of (+/-)-Norbakkenolide-A

The 5-exo-dig radical cyclisation reaction of the bromoacetals 9, obtained from the enol ethers 8, and treatment of the resulting hemiacetal 10 with Jones' reagent transforms the cyclic ketones 7 and 12 into α-spiro-β-methylene-γ-butyrolactones 11 and norbakkenolide-A 2.

Formation of trans Ring-Fused Compounds by an Alkylation-Radical Cyclization Sequence

Enolates derived from bicyclic lactones of type 1 (Scheme I) can be alkylated with 2-propynylic halides to give products 2, in which the unsaturated alkyl group is syn to the adjacent ring-fusion hydrogen.Reaction of 2 with sodium phenyl selenide and then