612494-85-6 Usage
Uses
Used in Pharmaceutical Industry:
6-Bromo-2-chloro-3-(3-chloropropyl)quinoline is used as a reagent for the preparation of competitive antagonists for the metabotropic glutamate receptor mGluR1. This application is significant because mGluR1 antagonists have potential therapeutic benefits in treating neurological disorders such as anxiety, depression, and Parkinson's disease. 6-BROMO-2-CHLORO-3-(3-CHLORO-PROPYL)-QUINOLINE's unique structure allows for the development of selective and potent antagonists that can modulate the activity of mGluR1, leading to improved treatment options for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 612494-85-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,2,4,9 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 612494-85:
(8*6)+(7*1)+(6*2)+(5*4)+(4*9)+(3*4)+(2*8)+(1*5)=156
156 % 10 = 6
So 612494-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H10BrCl2N/c13-10-3-4-11-9(7-10)6-8(2-1-5-14)12(15)16-11/h3-4,6-7H,1-2,5H2
612494-85-6Relevant academic research and scientific papers
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists
Mabire, Dominique,Coupa, Sophie,Adelinet, Christophe,Poncelet, Alain,Simonnet, Yvan,Venet, Marc,Wouters, Ria,Lesage, Anne S. J.,Van Beijsterveldt, Ludy,Bischoff, Fran?ois
, p. 2134 - 2153 (2007/10/03)
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC50/s
