409345-29-5 Usage
Uses
Used in Pharmaceutical Industry:
(3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE is used as a metabotropic glutamate receptor-1 antagonist for the treatment of neurological disorders. It has been shown to alter select behavior in mouse models of fragile X syndrome, a genetic disorder that leads to intellectual disability and social impairments.
Used in Research Applications:
(3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE is also used in research settings to study the role of metabotropic glutamate receptor-1 in various neurological processes and disorders. It can help researchers understand the underlying mechanisms of these conditions and develop new therapeutic strategies.
Used in Drug Development:
(3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE has potential as a lead compound in the development of new drugs targeting metabotropic glutamate receptor-1. Its unique structure and activity make it a promising candidate for further optimization and modification to improve its therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 409345-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,9,3,4 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 409345-29:
(8*4)+(7*0)+(6*9)+(5*3)+(4*4)+(3*5)+(2*2)+(1*9)=145
145 % 10 = 5
So 409345-29-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3/t13-,17+
409345-29-5Relevant academic research and scientific papers
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists
Mabire, Dominique,Coupa, Sophie,Adelinet, Christophe,Poncelet, Alain,Simonnet, Yvan,Venet, Marc,Wouters, Ria,Lesage, Anne S. J.,Van Beijsterveldt, Ludy,Bischoff, Fran?ois
, p. 2134 - 2153 (2007/10/03)
We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC50/s
