612503-08-9

Basic information

• Product Name: 2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine
• Synonyms: 2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine;2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-aMine
• CAS NO: 612503-08-9
• Molecular Formula: C₁₂H₁₁N₃S
• Molecular Weight: 229.30084
• Mol File: 612503-08-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine(612503-08-9)
• EPA Substance Registry System: 2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine(612503-08-9)

Safety Data

• Hazardous Substances Data: 612503-08-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-amine is used as a reactant in the preparation of olanzapine haptens. These haptens are essential for the production of antibodies that are useful in the determination and quantification of olanzapine, a widely prescribed antipsychotic medication. This application aids in ensuring the quality control and accurate measurement of olanzapine in pharmaceutical formulations, benefiting both the industry and patients receiving the medication.

Upstream product

• 873895-41-1 2-[(2-aminophenyl)amino]-5-methylthiophene-3-carbonitrile 
• 138564-59-7 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile 
• 1493-27-2 ortho-nitrofluorobenzene 
• 138564-58-6 2-amino-5-methylthiophene-3-carbonitrile 
• 138564-60-0 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydrochloride 

Downstream Products

• 161696-76-0 N-desmethyl olanzapine 
• 132539-06-1 zyprexa 
• 612503-69-2 (S)-2-methyl-10-(3-(3-phenyl-propyl)-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene 
• 612503-67-0 (S)-2-methyl-10-(3-(4-phenyl-butyl)-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene 

Relevant articles and documents

Method for producing intermediate olanzapine

PROBLEM TO BE SOLVED: To provide a method for producing an intermediate of olanzapine by a safe and simplified method without using tin chloride.SOLUTION: A method for producing a compound of formula 1 or its acid adduct is characterized by preparing a suspension containing a compound of formula 2, iron powder or zinc powder and a water-soluble alcohol and then adding an acid to the suspension to react them.

Antibodies to Olanzapine Haptens and Use Thereof

Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

ANTIBODIES TO OLANZAPINE HAPTENS AND USE THEREOF

Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

HAPTENS OF OLANZIPINE

The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS

Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C1-4) alkylene optionally substituted w