612542-08-2

Basic information

• Product Name: C₂₉H₃₈N₂O₈
• Synonyms: C₂₉H₃₈N₂O₈
• CAS NO: 612542-08-2
• Molecular Weight: 542.629
• Mol File: 612542-08-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₈N₂O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₈N₂O₈(612542-08-2)
• EPA Substance Registry System: C₂₉H₃₈N₂O₈(612542-08-2)

Safety Data

• Hazardous Substances Data: 612542-08-2(Hazardous Substances Data)

Upstream product

• 139009-66-8 (S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid 
• 1310720-65-0 ⁽³⁴¹⁾A₀₀₀₈₈₀ 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 31680-08-7 4-methoxy-3-nitrobenzaldehyde 

Relevant articles and documents

COMBRETASTATIN DERIVATIVE PREPARATION METHOD

The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P3 (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P2 having formula (IV) or P′2 having formula (V) so as to respectively obtain the compound P4 or P′4, which have formulas (VI) and (VII), respectively; then, during a step for deprotection in the presence of an acid and/or a base, the compound having P4 or P′4 leads, after an optional purification step, to the compound having formula (I) or (II).

METHOD FOR PREPARING COMBRETASTATIN

The Invention relates to a method for preparing a combretastatin (A): formula (I) in the form of a base or of an addition salt with an acid, which comprises coupling, in the presence of a base and of T3P, the salt of the (Z)-amino compound of formula (II)