139009-66-8

Basic information

• Product Name: (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID;(S)-N-Boc-2,2-diMethyloxazolidine-4-carboxylic Acid
• CAS NO: 139009-66-8
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.27
• Mol File: 139009-66-8.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID(139009-66-8)
• EPA Substance Registry System: (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID(139009-66-8)

Safety Data

• Hazardous Substances Data: 139009-66-8(Hazardous Substances Data)

Usage

General Description

"(S)-3-(Tert-Butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic Acid" is a chemical compound that belongs to the category of organic compounds known as oxazolidines. It is characterized by an oxazolidine ring which is a five-membered cyclic compound containing two carbon atoms, one nitrogen atom, and one oxygen atom. The term "tert-butoxycarbonyl" in its name signifies the presence of a protective group used primarily in peptide synthesis. Its primary role is to prevent unwanted peptide bond formation by temporarily blocking the reactive amine group during synthesis. Combined, all these characteristics suggest this chemical plays a role in pharmaceutical synthesis or other chemical synthetic processes requiring protective groups.

Upstream product

• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 95715-86-9 (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 77-76-9 2,2-dimethoxy-propane 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 95715-86-9 (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 122709-21-1 (4S)-2,2-Dimethyl-4-(N-methoxy-N-methylcarbamoyl)oxazolidin-3-carbonsaeure-(tert-butyl)ester 
• 785828-28-6 tert-butyl (4S)-4-acetyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 120005-55-2 (S)-tert-butyl 4-(hexadec-2-ynoyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1445860-11-6 C₄₃H₅₀N₈O₁₀S₂ 
• 1445860-12-7 C₂₆H₂₆N₄O₆S₂ 
• 1445860-21-8 C₂₇H₂₈N₄O₆S₂ 
• 1310720-65-0 ⁽³⁴¹⁾A₀₀₀₈₈₀ 
• 612542-08-2 C₂₉H₃₈N₂O₈ 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 115843-62-4 (S)-4-((S)-Benzyloxy-thiazol-2-yl-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Efficient construction of a doubly functionalized trisoxazole derivative relevant to the synthesis of the novel telomerase inhibitor telomestatin and its analogues

An efficient construction of a suitably functionalized trisoxazole derivative related to telomestatin was developed from L-serine, which involved three sequential oxazoline cyclization-oxidation steps in an overall yield of 11% in a linear sequence of twelve steps. Georg Thieme Verlag Stuttgart.

Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System

Nosiheptide is a ribosomally synthesized and post-translationally modified thiopeptide natural product that possesses antibacterial, anticancer, and immunosuppressive properties. It contains a bicyclic structure composed of a large macrocycle and a unique

Total synthesis of the azolemycins

The first total syntheses of newly isolated polyazole natural products azolemycins A-D, along with the synthesis of the tetra-oxazole non-natural analogue, are described.