61263-05-6Relevant academic research and scientific papers
A Convenient Procedure for the Synthesis of 2,2,2-Trifluoroethyl Methyl 2-Oxoalkylphosphonates
Molnár, Katalin,Behra, Julien,Takács, László,Kádár, Mihály,Kardos, Zsuzsanna,Faigl, Ferenc
supporting information, p. 677 - 680 (2015/07/20)
(Figure Presented) A convenient and versatile method was developed for the synthesis of 2,2,2-trifluoroethyl methyl 2-oxoalkylphosphonates starting from dimethyl phosphonates by alkaline hydrolysis followed by esterification with 2,2,2-trifluoroethanol using diisopropylcarbodiimide (DIC) in the presence of 4-(dimethylamino)pyridine (DMAP) catalyst following the Steglich protocol.
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity
Kambe, Tohru,Maruyama, Toru,Nakano, Masayuki,Nakai, Yoshihiko,Yoshida, Tadahiro,Matsunaga, Naoki,Oida, Hiroji,Konaka, Akira,Maruyama, Takayuki,Nakai, Hisao,Toda, Masaaki
scheme or table, p. 396 - 401 (2012/02/16)
A series of γ-lactam prostaglandin E1 analogs bearing a 16-phenyl moiety in the ω-chain and aryl moiety in the α-chain were synthesized and biologically evaluated. Among the tested compounds, γ-lactam PGE analog 3 designed as a structural hybrid of 1 and 2 was discovered as the most optimized EP2/EP4 dual agonist with excellent subtype-selectivity (Ki values: mEP2 = 9.3 nM, mEP4 = 0.41 nM). A structure-activity relationship study is presented.
Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists
Kambe, Tohru,Maruyama, Toru,Nakano, Masayuki,Yamaura, Yoshiyuki,Shono, Tomoyuki,Seki, Akiteru,Sakata, Kiyoto,Maruyama, Takayuki,Nakai, Hisao,Toda, Masaaki
, p. 1523 - 1534 (2012/01/13)
Analogs 8-aza-16-aryl prostaglandin E1 (PGE1) and 8-aza-5-thia-16-arylPGE1 were synthesized and evaluated with respect to their subtype receptor affinity and EP4 agonist activity for the purposes of identifying sub-type- selective EP
(15R)-16-m-Tolyl-17,18,19,20-tetranorisocarbacyclin: ein stabiler, hochselekiver Ligand mit hoher Bindungsaffinitaet fuer einen Prostacyclin-Rezeptor im zentralen Nervensystem
Suzuki, Masaaki,Kato, Koichi,Noyori, Ryoji,Watanabe, Yumiko,Takechi, Hajime,et al.
, p. 366 - 369 (2007/10/03)
Keywords: Prostacyclinrezeptoren; Molekulare Sonden; Tolylisocarbacyclin
