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Usage

Uses

Used in Chemical Industry:
(4,4-DiMethyloxetan-2-yl)Methanol is used as a solvent for various chemical processes, facilitating reactions and improving the efficiency of industrial production.
Used in Pharmaceutical Industry:
(4,4-DiMethyloxetan-2-yl)Methanol is used as an intermediate in the synthesis of various drugs, playing a crucial role in the development of new pharmaceuticals.
Used in Flavor and Fragrance Industry:
(4,4-DiMethyloxetan-2-yl)Methanol is used as a component in the manufacture of flavors and fragrances, contributing to the creation of diverse scents and tastes in consumer products.
Safety Considerations:
It is important to handle (4,4-DiMethyloxetan-2-yl)Methanol with care, as it can be harmful if it comes into contact with the skin or if it is inhaled, necessitating proper safety measures during its use and storage.

Upstream product

• 32932-25-5 α,α dimethyloxiranne ethoxybutyletain 
• 1067-52-3 tributyltin methoxide 
• 624-97-5 2-methylpent-4-en-2-ol 

Downstream Products

• 119205-26-4 4-Benzenesulfonylmethyl-2,2-dimethyl-oxetane 
• 122220-07-9 (E)-5-Benzenesulfonyl-2-methyl-pent-4-en-2-ol 

Relevant academic research and scientific papers

Preparation method and application of 2-hydroxymethyloxetane derivative

The invention discloses a preparation method and application of a 2-hydroxymethyloxetane derivative. The method comprises the following steps that a compound II and a compound III are used as raw materials; Barbier reaction is performed to obtain a compound IV; olefinic bonds in the compound IV are cyclized and oxidized to obtain a compound V; under the alkaline condition, ring opening is performed to generate a compound VI; after ring closing reaction, a compound VII is obtained; finally, benzyl protecting groups are removed to obtain the 2-hydroxymethyloxetane derivative (the compound I).

Novel pyrrolopyridine derivatives and its use as HIV inhibitor

The present invention relates to a pyrrolopyridine derivative expressed as chemical formula 1, specifically a compound including a substituent group having an oxatane group in R1, its stereoisomer or racemic body, their pharmaceutically acceptable salts or their solvate, a manufacturing method thereof, and an antivirus composition containing the same as an active ingredient, wherein the compound expressed as chemical formula 1 has excellent selectivity and physiological activity with respect to wild type or resistant HIV-1 and therefore can be used as a remedy for AIDS.

CONCERTED VERSUS STEPWISE PROCESSES IN ELIMINATIVE FISSION OF OXACYCLES

2-Phenylsulphonylmethyloxetan (2a) has been synthesised and the kinetics of base-promoted eliminative ring fission have been determined.The results show, by comparison with the behaviour of related substrates studied previously, that (i) the 3-ring,:4-rin

TRANSPOSITION DES OXIRANNES-ETHANOLS PAR L'INTERMEDIAIRE D'ALCOXYETAINS

Oxiraneethoxytributyltins prepared from the corresponding oxiraneethanols, on heating at 200 deg C gave, after demetalation with isophthalic acid, 2-oxetanemethanols and/or 3-oxolanols.As appears from about thirty rearrangements the choice between oxetane and oxolane formation is dependent on: (1) the relative degree of substitution of the oxirane ring; cyclization occuring predominantly at the more substituted carbon; and (2) the configuration of the oxirane ring, when both its ends are equally substituted; cis form being more suitable for genaration of the smaller ring.The reaction is shown to proceed with inversion of configuration at the site of oxygen attack.The results of attempts to perform the rearrangement in dilute-phase or throught alkaline metal alkoxides in various media support the conclusion that there is a large contribution by electrophilic assistance to the oxirane ring opening.Such assistance can be efficiently provided by a tin atom in a push-pull mechanism which accomodates all the facts.The present method of oxiraneethanol rearrangement may offer a convenient route to functional oxetanes.

TRANSPOSITION DES OXIRANNES-ETHANOLS PAR L'INTERMEDIAIRE D'ALCOXYETAINS. INFLUENCE DE LA CONFIGURATION DE L'OXIRANNE

The transposition of oxirane-ethanols, through alkoxytin compounds, into oxetane-2-methanols and/or oxolan-3-ols (tetrahydrofuran-3-ols) is dependent upon the oxirane configuration.Cis configuration is more suitable for the formation of the smallest ring.Steric hindrance is not sufficient enough to explain the results.