624-97-5

Usage

Uses

Used in Fragrance and Flavoring Industry:
2-METHYL-4-PENTEN-2-OL is used as a fragrance ingredient and flavoring agent for its sweet, floral scent and taste, contributing to the production of perfumes, soaps, and cosmetics.
Used in Chemical and Pharmaceutical Synthesis:
2-METHYL-4-PENTEN-2-OL is used as a precursor in the synthesis of various chemicals and pharmaceuticals, playing a crucial role in the development of new compounds.
Used in Synthetic Rubber and Plastics Production:
2-METHYL-4-PENTEN-2-OL is utilized in the production of synthetic rubber and plastics, enhancing the versatility and performance of these materials.
Used in Synthesis of Menthol and Vitamin E:
2-METHYL-4-PENTEN-2-OL is used as a precursor for the synthesis of other compounds such as menthol and vitamin E, which have various applications in the pharmaceutical, food, and cosmetic industries.
It is important to handle and store 2-METHYL-4-PENTEN-2-OL properly, as exposure to high concentrations can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C6H12O/c1-4-5-6(2,3)7/h4,7H,1,5H2,2-3H3

Upstream product

• 590-37-4 2-methylpent-4-yn-2-ol 
• 106-95-6 allyl bromide 
• 67-64-1 acetone 
• 107-05-1 3-chloroprop-1-ene 
• 43078-29-1 5-dimethylamino-2-methyl-pentan-2-ol 
• 53317-08-1 9-allyl-9-bora-bicyclo[3.3.1]nonane 
• 3900-79-6 toluene-4-sulfonic acid isopropylidenehydrazide 
• 18759-99-4 allyl(diethyl)borane 
• 2622-05-1 allylmagnesium bromide 
• 64549-05-9 allyldibutyltin chloride 
• 119-61-9 benzophenone 
• 1730-25-2 allylmagnesium bromide 
• 5497-67-6 2,2-dimethyl-4-pentenal 
• 36763-99-2 4-Hydroxy-4-methylvaleriansaeure-dimethylamid 

Downstream Products

• 6090-15-9 2,6-dimethylhept-5-en-2-ol 
• 926-56-7 4-methyl-1,3-pentadiene 
• 112481-90-0 2-<<(benzyloxy)methyl>oxy>-2-methyl-4-pentene 
• 763-30-4 2-methyl-1,4-pentadiene 
• 1118-58-7 1,3-Dimethyl-1,3-butadien 
• 67845-77-6 5-isopropenyl-1,3,4-trimethyl-cyclohexene 
• 64-18-6 formic acid 
• 625-08-1 3-Hydroxy-3-methylbutyric acid 
• 144-62-7 oxalic acid 
• 22092-57-5 2,9-dimethyl-2,9-decanediol 
• 61266-55-5 (4,4-dimethyloxetan-2-yl)methanol 
• 683-18-1 dibutyltin chloride 
• 1461-22-9 tributyltin chloride 
• 64549-05-9 allyldibutyltin chloride 

Relevant academic research and scientific papers

Selective synthesis of monoorganotin trihalides: The direct reaction of allylic halides with tin(II) halides catalyzed by platinum and palladium complexes

The reaction of 3-haloalkenes (3-chloropropene, 3-bromopropene, 3-chloro-2-methylpropene, 1-chloro-2-butene) with SnX2 (X=Cl, Br) to form mono-allyltin trihalides, was catalyzed by several platinum and palladium complexes of the type MZ2/

Patterning of a surface immobilized ATRP initiator with an inkjet printer

A new technique for patterning polymer brushes on the micrometer scale has been developed in which an inkjet printer was used to deposit droplets of acid on a surface-immobilized initiator for atom transfer radical polymerization (ATRP). The acid cleaved an ester bond in the ATRP initiator in a saponification reaction. As a result, the ATRP initiator was rendered inactive. To control the degree of defunctionalization, a new initiator containing a weak ester bond was derived from a tertiary alcohol. Comparison to an established ATRP initiator, derived from a primary alcohol, showed that the novel initiator was defunctionalized with a higher efficiency. Control of the reaction time allowed to partially defunctionalize the initiator molecules, leading to control of grafting densities within the written patterns.

Remote Arylative Substitution of Alkenes Possessing an Acetoxy Group via β-Acetoxy Elimination

Palladium-catalyzed remote arylative substitution was achieved for the reaction of arylboronic acids with alkenes possessing a distant acetoxy group to provide arylation products having an alkene moiety at the remote position. The use of β-acetoxy elimination as a key step in the catalytic cycle allowed for regioselective formation of unstabilized alkenes after chain walking. This reaction was applicable to various arylboronic acids as well as alkene substrates.

Primary Anion–π Catalysis of Epoxide-Opening Ether Cyclization into Rings of Different Sizes: Access to New Reactivity

The concept of anion–π catalysis focuses on the stabilization of anionic transition states on aromatic π surfaces. Recently, we demonstrated the occurrence of epoxide-opening ether cyclizations on aromatic π surfaces. Although the reaction proceeded through unconventional mechanisms, the obtained products are the same as those from conventional Br?nsted acid catalysis, and in agreement with the Baldwin selectivity rules. Different mechanisms, however, should ultimately lead to new products, a promise anion–π catalysis has been reluctant to live up to. Herein, we report non-trivial reactions that work with anion–π catalysis, but not with Br?nsted acids, under comparable conditions. Namely, we show that the anion–π templated autocatalysis and epoxide opening with alcoholate–π interactions can provide access to unconventional ring chemistry. For smaller rings, anion–π catalysis affords anti-Baldwin oxolanes, 2-oxabicyclo[3.3.0]octanes, and the expansion of Baldwin oxetanes by methyl migration. For larger rings, anion–π templated autocatalysis is thought to alleviate the entropic penalty of folding to enable disfavored anti-Baldwin cyclizations into oxepanes and oxocanes.

Preparation method and application of 2-hydroxymethyloxetane derivative

The invention discloses a preparation method and application of a 2-hydroxymethyloxetane derivative. The method comprises the following steps that a compound II and a compound III are used as raw materials; Barbier reaction is performed to obtain a compound IV; olefinic bonds in the compound IV are cyclized and oxidized to obtain a compound V; under the alkaline condition, ring opening is performed to generate a compound VI; after ring closing reaction, a compound VII is obtained; finally, benzyl protecting groups are removed to obtain the 2-hydroxymethyloxetane derivative (the compound I).

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

Novel pyrrolopyridine derivatives and its use as HIV inhibitor

The present invention relates to a pyrrolopyridine derivative expressed as chemical formula 1, specifically a compound including a substituent group having an oxatane group in R1, its stereoisomer or racemic body, their pharmaceutically acceptable salts or their solvate, a manufacturing method thereof, and an antivirus composition containing the same as an active ingredient, wherein the compound expressed as chemical formula 1 has excellent selectivity and physiological activity with respect to wild type or resistant HIV-1 and therefore can be used as a remedy for AIDS.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Dibutyltin oxide mediated diastereoselective cyclodehydration/sulfonylation of 1,2,4-triols

Dibutyltin oxide (Bu2SnO) mediated cyclodehydration or sulfonylation of 1,2,4-triols is predictably diastereoselective depending on the steric bulk of the substituents at C4. A larger difference (ΔA-value >1 kcal/mol) leads to the syn-1,2,4-triols favouring cyclodehydration (78-85%) to form 3-hydroxytetrahydrofurans, with the anti-1,2,4-triols favouring monosulfonylation (66-87%). Triols from symmetrical ketones preferentially undergo cyclodehydration in high yield (>75%) due to a gem-disubstituent effect. Thus, the 1,2,4-triols derived from simple cyclic ketones also favour cyclodehydration to form spirocyclic 3-hydroxytetrahydrofurans in 72-79% yields.