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61276-17-3 Usage


Verbascoside, a phenolic antioxidant agent, is a white solid compound isolated from Lantana camara. It acts as an ATP-competitive inhibitor of protein kinase C (PKC) with an IC50 of 25 μM and exhibits antitumor, anti-inflammatory, and antineuropathic pain activities.


Used in Pharmaceutical Industry:
Verbascoside is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. It is particularly effective in treating glomerulonephritis, a type of kidney inflammation.
Used in Antitumor Applications:
Verbascoside is used as an antitumor agent due to its potential to inhibit tumor growth and progression. It may be employed in the development of novel cancer treatments and therapies.
Used in Antineuropathic Pain Management:
Verbascoside is used as an antineuropathic pain agent for its ability to alleviate pain associated with nerve damage or dysfunction.
Used in Oxidative Stress Reduction:
As a phenolic antioxidant agent, Verbascoside is used to protect cells from oxidative stress and damage, which can contribute to various diseases and conditions.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Enzyme inhibitor

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Check Digit Verification of cas no

The CAS Registry Mumber 61276-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,2,7 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 61276-17:
113 % 10 = 3
So 61276-17-3 is a valid CAS Registry Number.

61276-17-3 Well-known Company Product Price

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  • (00820580)  Verbascoside  primary pharmaceutical reference standard

  • 61276-17-3

  • 00820580-10MG

  • 4,743.18CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name Verbascoside

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61276-17-3 SDS

61276-17-3Relevant articles and documents

An Approach to the Synthesis of Electron-Rich and Hindered Esters and Its Application to the Synthesis of Acteoside

Zhang, Xiaojuan,Yang, Yutong,Wang, Fuye,Zhou, Zhengbing,Zhang, Hongbin,Zhu, Yugen

supporting information, p. 9210 - 9215 (2021/11/30)

Electron-rich esters are ubiquitously distributed in natural products and play a central role in bioactivities. Herein, we disclose an efficient, mild, and general esterification approach to the synthesis of these esters by employing gold(I)-catalyzed acylation reaction with alkyne-tethered mixed anhydrides and alcohols. This method can be applied to ester-bond formation in complex substrates and facilitates efficient synthesis of acteoside, which belongs to the family of phenylethanoid glycosides and possesses a broad range of bioactivities.

Total Synthesis of the Phenylpropanoid Glycoside, Acteoside

Kawada, Toshinari,Asano, Ryuji,Hayashida, Shiho,Sakuno, Tomoyasu

, p. 9268 - 9271 (2007/10/03)



Oganesyan, G. B.,Galstyan, A. M.,Mnatsakanyan, V. A.,Shashkov, A. S.,Agababyan, P. V.

, p. 556 - 559 (2007/10/02)

Together with poliumoside we have isolated for the first time from golden germander verbascoside and a new phenylpropanoid glycoside (teupolioside) for which the structure of 2-(3,4-dihydroxyphenyl)ethyl O-β-D-galactopyranosyl-(1->2)-O-α-L-rhamnopyranosyl-(1->3)-4-O-caffeoyl-β-D-glucopyranoside is proposed.A mixture of poliumoside and teupolioside revealed a moderate antibacterial activity.

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