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61276-17-3

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Product FOB Price Min.Order Supply Ability Supplier
TOP Supplier Cistanche Tubulosa Extract-Echinacoside/Acteoside/Verbascoside98%
Cas No: 61276-17-3
USD $ 8.0-8.0 / Metric Ton 1 Metric Ton 100000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
Acteoside; Verbascoside
Cas No: 61276-17-3
No Data 20 Milligram Metric Ton/Day Chengdu Alfa Biotechnology Co.,Ltd. Contact Supplier
Acteoside manufacturer
Cas No: 61276-17-3
No Data No Data No Data Shanghai Yuanye Bio-Technology Co., Ltd. Contact Supplier
Verbascum Thapsus Extract
Cas No: 61276-17-3
USD $ 20.0-20.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
Verbascoside
Cas No: 61276-17-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Natural Cistanche Tubulosa Extract CAS:61276-17-3
Cas No: 61276-17-3
USD $ 600.0-700.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Acteoside in stock CAS 61276-17-3
Cas No: 61276-17-3
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High Quality 5% Verbascoside/Ergosteride Powder From Cistanche Extract
Cas No: 61276-17-3
USD $ 183.0-200.0 / Kilogram 1 Kilogram 10000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Verbascoside
Cas No: 61276-17-3
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Natural Extract 98% Verbascoside 61276-17-3 HACCP Manufacturer
Cas No: 61276-17-3
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

61276-17-3 Usage

Description

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Enzyme inhibitor

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Chemical Properties

White solid
InChI:InChI=1/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1

61276-17-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (00820580)  Verbascoside  primary pharmaceutical reference standard 61276-17-3 00820580-10MG 4,743.18CNY Detail

61276-17-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Verbascoside

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61276-17-3 SDS

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