612820-83-4Relevant academic research and scientific papers
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
McIntyre, Charles J.,McCauley, John A.,Bednar, Bohumil,Bednar, Rodney A.,Butcher, John W.,Claremon, David A.,Cunningham, Michael E.,Freidinger, Roger M.,Gaul, Stanley L.,Homnick, Carl F.,Koblan, Ken S.,Mosser, Scott D.,Romano, Joseph J.,Liverton, Nigel J.
scheme or table, p. 5132 - 5135 (2010/03/31)
A novel series of annulated tricyclic compounds was synthesized and evaluated as NMDA/NR2B antagonists. Structure-activity development was directed towards in vitro optimization of NR2B activity and selectivity over the hERG K+ channel. Preferr
5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDINE NMDA/NR2B ANTAGONISTS
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Page/Page column 42; 45-46, (2010/02/07)
Benzo [4,5]cyclohepta[1,2-b]pyridines represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
