612832-86-7Relevant academic research and scientific papers
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten- 1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain
Giblin, Gerard M.P.,Bit, Rino A.,Brown, Susan H.,Chaignot, Helene M.,Chowdhury, Anita,Chessell, Iain P.,Clayton, Nicholas M.,Coleman, Tanya,Hall, Adrian,Hammond, Beverley,Hurst, David N.,Michel, Anton D.,Naylor, Alan,Novelli, Riccardo,Scoccitti, Tiziana,Spalding, David,Tang, Sac P.,Wilson, Alex W.,Wilson, Rich
, p. 385 - 389 (2007)
The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated
(2-((2-ALKOXY) -PHENYL) -CYCLOPENT-1-ENYL) AROMATIC CARBO AND HETEROCYCLIC ACID AND DERIVATIVES
-
Page/Page column 26-27; 29-30; 62, (2010/02/07)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
