61292-49-7

Usage

Appearance

White crystalline solid

Applications

a. Pharmaceuticals
b. Agrochemicals
c. Dyes

Potential properties

a. Antiviral
b. Antifungal
c. Antibacterial

Enzyme inhibition

Investigated for its potential to inhibit certain enzymes

Synthesis

Used in the synthesis of other organic compounds due to its reactivity and versatility

Safety

Handle with care due to potential toxic and irritating effects

Upstream product

• 288-32-4 1H-imidazole 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 4238-71-5 1-benzylimidazole 
• 612-23-7 2-nitrobenzyl chloride 

Downstream Products

• 78105-32-5 1-(o-nitrobenzyl)-2-hydroxymethylimidazole 
• 153776-33-1 1-(2-nitrobenzyl)-2-trichloroacetyl-1H-imidazole 
• 61292-50-0 1-(2-imidazolylmethyl)aniline 
• 401495-63-4 furan-2-yl-[1-(2-nitro-benzyl)-1H-imidazol-2-yl]-methanone 
• 401495-62-3 [1-(2-nitro-benzyl)-1H-imidazol-2-yl]-thiophen-2-yl-methanone 
• 401495-60-1 (4-fluoro-phenyl)-[1-(2-nitro-benzyl)-1H-imidazol-2-yl]-methanone 
• 97420-72-9 1-(2-nitrobenzyl)-2-ethoxycarbonyl-1H-imidazole 
• 97420-74-1 1-(2-aminobenzyl)-2-ethoxycarbonyl-1H-imidazole 
• 102432-53-1 (2-Imidazol-1-ylmethyl-phenyl)-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 102432-55-3 N-(4-{[(E)-2-Imidazol-1-ylmethyl-phenylimino]-methyl}-phenyl)-acetamide 
• 102432-57-5 (2-Imidazol-1-ylmethyl-phenyl)-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 102432-52-0 (2-Imidazol-1-ylmethyl-phenyl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 102432-56-4 [1-(2,4-Dichloro-phenyl)-meth-(E)-ylidene]-(2-imidazol-1-ylmethyl-phenyl)-amine 
• 102432-54-2 C₁₉H₂₀N₄ 

Relevant academic research and scientific papers

Mono-nitration of aromatic compounds via their nitric acid salts

Aromatic compounds bearing a basic nitrogen atom can be converted to the corresponding nitric acid salts. Mono-nitration of the compounds can be carried out by adding a dichloromethane solution of the salts to sulfuric acid, or by adding acetyl chloride (or trifluoroacetic anhydride) to a dichloromethane solution of the salts. This protocol provides, among other benefits, the most convenient and reliable way for the prevention of over-/under-nitration and is especially suitable for scale-up.

Mono-nitration of aromatic compounds via nitrate salts

A method of nitrating a compound selected from the group consisting of is provided.

Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles

Compounds of the formula STR1 wherein Z is a direct bond or alkylene of 1 - 3 carbon atoms which is unsubstituted or substituted on the carbon atom alpha to the phenyl group by alkyl or unsubstituted or substituted phenyl, R2 and R3 singly are H, alkyl, alkoxy, alkylmercapto, halo, nitro or, collectively, C4 H4, and R4 is alkenyl, alkinyl, unsubstituted or substituted phenyl or phenylalkyl, or, when Z is substituted methylene, also alkyl, are useful in combating Germatophyte infections, especially Trichophyton rubrum and mentagrophytes, and yeast infections, especially Candida albicans, as well as bacterial and fungal infections.