61308-25-6

Basic information

• Product Name: Piperazine, 1-(2-chloroethyl)- (7CI,9CI)
• Synonyms: Piperazine, 1-(2-chloroethyl)- (7CI,9CI)
• CAS NO: 61308-25-6
• Molecular Formula: C₆H₁₃ClN₂
• Molecular Weight: 148.63382
• Product Categories: PIPERAZINE
• Mol File: 61308-25-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-(2-chloroethyl)- (7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(2-chloroethyl)- (7CI,9CI)(61308-25-6)
• EPA Substance Registry System: Piperazine, 1-(2-chloroethyl)- (7CI,9CI)(61308-25-6)

Safety Data

• Hazardous Substances Data: 61308-25-6(Hazardous Substances Data)

Usage

General Description

Piperazine, 1-(2-chloroethyl)- (7CI,9CI) is a chemical compound with the molecular formula C6H13ClN2. It is a derivative of piperazine, a heterocyclic organic compound with a six-membered ring containing two nitrogen atoms. The 2-chloroethyl group in this compound makes it useful in the synthesis of various pharmaceuticals and organic compounds. It is commonly used as an intermediate in the manufacturing of drugs such as antihistamines, antipsychotics, and antimalarial agents. Additionally, it has been studied for its potential role as an antitumor agent. The compound is also utilized in research and development for the synthesis of novel chemical entities with potential biological activity.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 110-85-0 piperazine 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 3644-18-6 N-(2-(dimethylamino)ethyl)piperazine 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 4892-89-1 4-(2-(piperazin-1-yl)ethyl)morpholine 
• 208167-83-3 tert-butyl 4-(2-chloroethyl)tetrahydro-1(2H)-pyrazinecarboxylate 

Relevant articles and documents

Preparation method of 4-morpholinyl-2-ethylpiperazine

The invention discloses a preparation method of 4-morpholinyl-2-ethylpiperazine. The method comprises the following steps: (1) putting 2-hydroxyethylpiperazine and thionyl chloride into a first solvent, and performing a reaction to convert hydroxyl groups into chlorine to obtain a first reaction product; (2) putting the first reaction product obtained in step (1) and boc anhydride into a second solvent, and performing a reaction to obtain an N-boc protected second reaction product; (3) putting the second reaction product obtained in step (2), morpholine and an acid-binding agent into a third solvent at 20-50 DEG C, and performing a reaction to obtain a third reaction product; and (4) dissolving the third reaction product obtained in step (3) and an alkali in a fourth solvent, heating the obtained solution to 40-80 DEG C, performing a reaction for about 10-20 h, concentrating the obtained reaction solution, and extracting and concentrating the obtained concentrate to obtain the 4-morpholinyl-2-ethylpiperazine. Raw materials used in the method are cheap and are easy to obtain, the operation process is simple, and the purity of the obtained product is high and exceeds 99%.