6131-59-5

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-2-Methoxypropanol is used as a solvent for facilitating the dissolution of various pharmaceutical compounds, which is essential for the development and manufacturing of medications.
Used in Agrochemical Industry:
(R)-(-)-2-Methoxypropanol is used as a solvent in the production of agrochemicals, such as pesticides and herbicides, to improve the solubility and effectiveness of these products.
Used in Fragrance Industry:
(R)-(-)-2-Methoxypropanol is used as a solvent in the formulation of fragrances, helping to dissolve and stabilize the aromatic compounds that create the desired scents.
Used in Resin Manufacturing:
(R)-(-)-2-Methoxypropanol is used as a solvent in the production of resins, which are essential components in the manufacturing of various products, including plastics, coatings, and adhesives.
Note: Extreme caution must be exercised when handling (R)-(-)-2-Methoxypropanol as it poses potential health risks, including the possibility of serious eye damage.

InChI:InChI=1/C4H10O2/c1-4(3-5)6-2/h4-5H,3H2,1-2H3/t4-/m1/s1

Upstream product

• 67-56-1 methanol 
• 15448-47-2 (R)-propylene oxide 
• 16088-62-3 (S)-Propylene oxide 

Relevant academic research and scientific papers

Generation of a solid Bronsted acid site in a chiral framework

Protonation of chiral porous materials introduces a Bronsted acid centre, the structure of which is unique to the heterogeneous phase requiring pore wall confinement for stable isolation. The Royal Society of Chemistry.

Mechanisms and stereochemistry of acid-induced ring opening of optically active 1,2-propene oxides in the gas phase

The acid-induced ring opening of (S)-(-)-1,2-propene oxide (1S) and (R)-(+)-1,2-propene oxide (1R) has been investigated in gaseous CH4 and CH3F at 720 torr and in the presence of a nucleophile, NuOH (Nu = H or CH3). The mechanism of the ring-opening reaction has been assessed by modulating the composition of the gaseous mixture. Two reaction pathways are operative in the gas phase, both proceeding through complete inversion of configuration of the reaction center. A first process is detectable only in the CH3F/H2O systems and takes place within a persistent proton-bound complex generated by interaction of the epoxide with the CH3OH2/+ ion, formed by methylation of H2O with (CH3)2F+. Such an intracomplex ring-opening pathway proceeds through proton transfer from the CH3OH2/+ ion to the epoxide followed by motion of the neutral CH3OH moiety around the 1-H-oxonia-2-methyl-cyclopropane structure (H-1R or H-1S) (k8 s-1) before attacking the ring carbons from the rear. In all the other systems with added CH3OH, this intracomplex pathway is preceded by a faster 'extracomplex' pathway involving the attack of an external CH3OH molecule on the proton-bound adduct. The regioselectivity of the intracomplex process is similar to that of the extracomplex pathway. Both are characterized by a slight preference for the Cβ center of H-1 R (or H-1S) (extra-complex path regioselectivity: α/β = 0.72 ± 0.05; intracomplex path regioselectivity: α/β= 0.71 ± 0.05). The regioselectivity of H-1 R (or H-1S) is substantially different from that of the 1-Me-oxonia-2-methyl-cyclopropanes (Me-1 R or Me-1S) toward the same nucleophile NuOH (α/β = 4.13 ± 0.35 (Nu = H); 2.28 ± 0.16 (Nu = CH3)). This difference is attributed to a transition structure wherein the Cα-O bond rupture increases from H-1 R (or H-1S) to Me-1R (or Me-1S) and in passing from CH3OH to H2O. The regio- and stereoselectivity of the gas-phase acid-induced ring opening of 1 S and 1 R are compared with those of related reactions carried out in solution.