61310-39-2

Basic information

• Product Name: 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE
• Synonyms: 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE
• CAS NO: 61310-39-2
• Molecular Formula: C9H8N4O
• Molecular Weight: 188.19
• Mol File: 61310-39-2.mol

Chemical Properties

• Boiling Point: 364.8±52.0 °C(Predicted)
• Appearance: /
• Density: 1.46±0.1 g/cm3(Predicted)
• PKA: 7.93±0.50(Predicted)
• CAS DataBase Reference: 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE(61310-39-2)
• EPA Substance Registry System: 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE(61310-39-2)

Safety Data

• Hazardous Substances Data: 61310-39-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Pyridyl)-4-amino-6-hydroxy pyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activity and potential use in the treatment of various diseases and disorders.
Used in Agrochemical Industry:
2-(4-Pyridyl)-4-amino-6-hydroxy pyrimidine is used as an intermediate in the synthesis of agrochemicals for its potential applications in the development of new drugs and therapies.

Upstream product

• 6345-27-3 4-amidinopyridine hydrochloride 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant articles and documents

2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS

4-Aminopyrimidine derivatives of formula (I) FORMULA heteroaryl groups, including pharmaceutically acceptable salts thereof, wherein R1 and R2 are adenosine A2A receptor antagonists useful in the treatment of movement disorders such as Parkinson's disease.

N-[2-(pyridinyl)-4-pyrimidinyl]ureas

Compounds useful as anti-allergic agents are N-R3 -N-R4 -N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)ureas (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R1 is hydrogen, lower-alkyl or cyano, R2 is hydrogen or lower-alkyl, R3 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R4 is hydrogen, lower-alkyl, lower-hydroxyalkyl, lower-alkenyl or lower-cycloalkyl. Said ureas are prepared by reacting 2-Q-4-RNH-5-R1 -6-R2 -pyrimidine (II) with a carbamylating agent selected from an R4 '-isocyanate of the formula R4 'N=C=O to produce N-R4 '-N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IA), an N-R3 '-N-R4 '-carbamyl halide of the formula R3 'R4 'NC(=O)-halide to produce N-R3 '-N-R4 'N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IB) or 1,1'-carbonyldiimidazole to produce N-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)-N-R-imidazole-1-carboxamide and then reacting said 1-carboxamide with R3 R4 NH to produce I.

N-(2-(pyridinyl)-4-pyrimidinyl)-aminomethylenemalonates and analogs

Compounds useful as anti-allergic agents are 2-Q-4-[XZC=C(R)NH]-5-R1 -6-R2 -pyrimidines (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R1 is hydrogen, lower-alkyl or cyano, R2 is hydrogen, lower-alkyl, hydroxy or halo, X and Z are the same or different and are each selected from lower-carbalkoxy, lower-alkanoyl, carbamyl and cyano, or STR1 where R3 and R4 are each lower-alkyl, or X is hydrogen, are prepared by reacting 4-amino-2-Q-5-R1 -6-R2 -pyrimidine (II where Q' is amino) with R'O-C-(R)=CXZ (III). Preparations of II are given. Also shown as intermediates and/or anti-allergic agents are 4-(AcNH)-2-Q-5-R1 -6-R2 -pyrimidines (IV) and 4-(R5 R6 N)-2-Q-5-R1 -6-R2 -pyrimidines (V) where Ac is lower-alkanoyl or lower-carbalkoxy, R5 is hydrogen, lower-alkyl or lower-hydroxyalkyl, and R6 is lower-alkyl or lower-hydroxyalkyl.