61315-87-5

Upstream product

• 106-94-5 propyl bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 6314-88-1 1,2,5,6-tetrahydrobenzaldehyde diethyl acetal 
• 100-50-5 3-Cyclohexene-1-carboxaldehyde 
• 71-23-8 propan-1-ol 

Downstream Products

• 99856-22-1 5-(trans-2-Nitro-vinyl)-2-propoxy-phenol 
• 76799-23-0 2,3'-dihydroxy-4-(carboxymethoxy)-4'-propoxy-6-(benzyloxy)chalcone 
• 61497-72-1 3-(benzyloxy)-4-propoxybenzaldehyde 
• 943749-68-6 3-hydroxy-4-propoxybenzaldehyde O-methyloxime 
• 76799-46-7 2,3',6-tris(benzyloxy)-4-<1-(carbo-tert-butoxy)-3,4-epoxybutoxy>-4'-propoxychalcone 
• 76799-40-1 2,3',6-tris(benzyloxy)-4-hydroxy-4'-propoxychalcone 
• 76820-14-9 2,3',6-trihydroxy-4-<1-(carbo-tert-butoxy)-3,4-dihydroxybutoxy>-4'-propoxydihydrochalcone 
• 76820-13-8 2,3',6-trihydroxy-4-(1,3-dicarbomethoxypropoxy)-4'-propoxydihydrochalcone 

Relevant academic research and scientific papers

Coenzyme A-Conjugated Cinnamic Acids – Enzymatic Synthesis of a CoA-Ester Library and Application in Biocatalytic Cascades to Vanillin Derivatives

We present a bioorthogonal method for the ligation of coenzyme A (CoA) with cinnamic acids. The reaction, which is the initial step in the biosynthesis of a multitude of bioactive secondary metabolites, is catalyzed by a promiscuous plant ligase and yields CoA conjugates with different functionalization in high purity and without formation of by-products. Its applicability in biosynthetic cascades is shown for the direct transformation of cinnamic acids into natural benzaldehydes (like vanillin) or artificial derivatives (e. g. ethylvanillin). (Figure presented.).

A (3 - alkoxy - 4 - hydroxy) - cyclohexyl acetal glycol and its isomers of use

The present invention discloses a (3-alkoxy-4-hydroxy)-cyclohexyl methylal diol, an (3-hydroxy-4-alkoxy)-cyclohexyl methylal diol and synthesis methods and use therefor. The (3-alkoxy-4-hydroxy)-cyclohexyl methylal diol and (3-hydroxy-4-alkoxy)-cyclohexyl methylal diol can be used for synthesis of a variety of vanillin and iso-vanillin. Compared to the existing synthetic method, the synthesis method has simple steps, and less discharge of "three wastes".

A 3, 4 - epoxy-cyclohexane METHYLAL glycol and its synthesis and use

The invention discloses a 3,4-epoxy cyclohexyl methylal diol and a synthesis method thereof. The 3,4-epoxy cyclohexyl methylal diol can be used for synthesizing multiple vanillins and isovanillins. Compared with the existing synthesis process, the synthesis method disclosed by the invention has the advantages of simple steps and low discharge amount of three wastes.

Studies on synthesis and structure-activity relationship (SAR) of derivatives of a new natural product from marine fungi as inhibitors of influenza virus neuraminidase

Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC50 values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1), 27.73 μM for A/Guangdong/03/2009 (H1N1), and 25.13 μM for A/Guangdong/05/2009 (H1N1), respectively, which is stronger than the benzoic acid derivatives (～mM level). These are a new kind of non-nitrogenous aromatic ether Neuraminidase (NA) inhibitors. Their structures are simple and the synthesis routes are not complex. The structure-activity relationship (SAR) analysis revealed that the aryl aldehyde and unsubstituted hydroxyl were important to NA inhibitory activities. Molecular docking studies were carried out to explain the SAR of the compounds, and provided valuable information for further structure modification.

Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4

The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminometh-ylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here represents a novel class of potential antitumor agents, which potently and selectively inhibit CDK4 over CDK2 and CDK1. In the benzylamino headpiece, a 3-OH substituent is required on the phenyl ring for CDK4 inhibitory activity, which is further enhanced when an iodo, aryl, heteroaryl, t-butyl, or cyclopentyl substituent is introduced at the C-6 position of the isoquinoline-1,3-dione core. To circumvent the metabolic liability associated with the phenolic OH group on the 4-substituted 3-OH phenyl headpiece, we take two approaches: first, introduce a nitrogen o- or p- to the 3-OH group in the phenyl ring; second, replace the phenyl headpiece with N-substituted 2-pyridones. We present here the synthesis, SAR data, metabolic stability data, and a CDK4 mimic model that explains the binding, potency, and selectivity of our CDK4 selective inhibitors.

NOVEL BICYCLIC AND TRICYCLIC PYRROLIDINE DERIVATIVES AS GNRH ANTAGONISTS

Bicyclic and tricyclic pyrrolidine derivatives are disclosed that are useful as antagonists of the GnRH receptor. Methods for using the novel compounds to treat GnRH-related disorders are also provided, as are pharmaceutical compositions and novel synthetic methods.