61317-65-5

Basic information

• Product Name: 1-(2,2-difluorovinyl)-2-fluorobenzene
• Synonyms: 1-(2,2-difluorovinyl)-2-fluorobenzene
• CAS NO: 61317-65-5
• Molecular Weight: 158.123
• Mol File: 61317-65-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluorovinyl)-2-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluorovinyl)-2-fluorobenzene(61317-65-5)
• EPA Substance Registry System: 1-(2,2-difluorovinyl)-2-fluorobenzene(61317-65-5)

Safety Data

• Hazardous Substances Data: 61317-65-5(Hazardous Substances Data)

Upstream product

• 19740-19-3 chlorodifluoroacetic acid lithium salt 
• 446-52-6 2-Fluorobenzaldehyde 
• 2925-16-8 1,1-difluoro-2-iodoethylene 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 75-61-6 dibromodifluoromethane 
• 124004-75-7 α,α,α-trifluoro-2-fluoroacetophenone 

Downstream Products

• 326-62-5 2-fluorophenyl acetonitrile 
• 93524-63-1 1,1-difluoro-2-(2'-fluorophenyl)ethane 

Relevant articles and documents

Proton-Transfer Reactions. 3. Differences in the Protonation of Localized and Delocalized Carbanion Intermediates

Rates, activation parameters, and product distributions are reported for the reaction of methanolic sodium methoxide with XC6H4CH = CF2 (V) and C6F5CH = CF2 (IX) and compared to previously reported results for C6H5C(CF3) = CF2 (I).A ρ = 3.5 was calculated

Fluorinated phosphonium ylides: Versatile in situ Wittig intermediates in the synthesis of hydrofluorocarbons

A simple and convenient technique has been developed for the synthesis, characterisation and isolation of hydrofluoro/hydrohalofluorocarbons such as chlorodifluoromethane (CF2ClH), difluoromethane (CF2H2), bromodifluoromethane (CF2BrH) and dibromofluoromethane (CFBr2H) as possible chlorofluorocarbon (CFC) alternatives. The Wittig reaction of carbonyl compounds with in situ generated triphenylphosphonium ylides in DMF forms terminal fluoroolefins. However, in the absence of the carbonyl moiety these ylides undergo decomposition. The high reactivity of fluoromethylene triphenylphosphonium ylides in DMF in the absence of the carbonyl moiety has been exploited for the first time to design the synthesis of hydrofluorocarbons.

A New Route for the Preparation of Substituted 2,2-Difluorostyrenes and a Convenient Route to Substituted (2,2,2-Trifluoroethyl)benzenes

The (2,2-difluoroethenyl)zinc reagent II is coupled with aryl iodides or bromides in the presence of Pd(PPh3)4 in DMF to give the corresponding 2,2-difluorostyrenes IV. The 4-substituted (tetrafluoroaryl)copper reagents are coupled with 2,2-difluoro-1-iodoethylene (I) to produce the corresponding styrene derivatives VII. Both methods provide good yields of the coupled products. These products react with wet KF in DMF or DMSO to form the (2,2,2-trifluoroethyl)benzene derivatives VIII in good yields.