61318-90-9 Usage
uses
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
Indications
Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is
structurally related to the other imidazole antifungals (ketoconazole, econazole,
and miconazole). It is postulated to inhibit 14-α-demethylase for
decreased ergosterol synthesis, increased cell membrane permeability, and
resultant cell death. It is active against most dermatophytes, yeast, and
P. orbiculare. It also displays activity against some aerobic and anaerobic
gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450
microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce
the metabolism of other drugs.
Definition
ChEBI: A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.
Synthesis
Sulconazole, 1-[2,4-dichloro-β-[(4-chlorobenzyl)thio]phenethyl]-imidazole
(35.2.9), is an analog of exonazole. It differs in the replacement of the etheral oxygen
bridge (which connects the 4-chlorobenzyl part of the molecule with phenethylimidazole)
for a thioether bond. The corresponding changes in the synthesis of this drug are the
replacement of the hydroxyl group in 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)-ethanol
(35.2.6) with a chlorine atom using thionyl chloride, followed by a reaction of the resulting chloride with 4-chlorobenzylmercaptane to make sulconazole.
Check Digit Verification of cas no
The CAS Registry Mumber 61318-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,1 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61318-90:
(7*6)+(6*1)+(5*3)+(4*1)+(3*8)+(2*9)+(1*0)=109
109 % 10 = 9
So 61318-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
61318-90-9Relevant articles and documents
1-Phenethylimidazoles
-
, (2008/06/13)
Novel 1-phenethylimidazoles substituted at the position β to the imidazole ring by an optionally substituted hydrocarbyl ester, thioester, or dithioester are useful as antimicrobial agents and as intermediates in the preparation of novel 1-phenethylimidazoles substituted at the position β to the imidazole with a mercapto. Both the former and latter compounds are useful as intermediates in the preparation of certain 1-[β-(R-thio)phenethyl] imidazoles.
