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Usage

Uses

Used in Pharmaceutical Industry:
(R)-Sulconazole is used as a topical antifungal agent for treating various fungal infections such as athlete's foot, jock itch, and ringworm. It is effective in inhibiting fungal growth and preventing the spread of infections, offering relief from symptoms and promoting skin health.
Used in Dermatology:
(R)-Sulconazole is used as a therapeutic agent for skin conditions caused by fungal infections. Its application helps alleviate symptoms like itching, redness, and discomfort, making it a valuable tool in dermatological treatments.
Used in Over-the-counter Medications:
(R)-Sulconazole is used as an active ingredient in over-the-counter antifungal products, providing consumers with an accessible and convenient option for treating mild to moderate fungal infections without the need for a prescription.

Upstream product

• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 1165796-83-7 (R)-2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethanamine 
• 61318-90-9 sulconazole 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 55954-23-9 methyl 2-(2,4-dichlorophenyl)acetate 
• 622-95-7 4-chlorobenzyl bromide 
• 1165796-81-5 C₁₀H₁₁Cl₂NOS 

Relevant academic research and scientific papers

Stereospecific modulation of dimeric rhodopsin

The classic concept that GPCRs function as monomers has been challenged by the emerging evidence of GPCR dimerization and oligomerization. Rhodopsin (Rh) is the only GPCR whose native oligomeric arrangement was revealed by atomic force microscopy demonstrating that Rh exists as a dimer. However, the role of Rh dimerization in retinal physiology is currently unknown. In this study, we identified econazole and sulconazole, two small molecules that disrupt Rh dimer contacts, by implementing a cell-based high-throughput screening assay. Racemic mixtures of identified lead compounds were separated and tested for their stereospecific binding to Rh using UV-visible spectroscopy and intrinsic fluorescence of tryptophan (Trp) 265 after illumination. By following the changes in UV-visible spectra and Trp265 fluorescence in vitro, we found that binding of R-econazole modulates the formation of Meta III and quenches the intrinsic fluorescence of Trp265. In addition, electrophysiological ex vivo recording revealed that R-econazole slows photoresponse kinetics, whereas S-econazole decreased the sensitivity of rods without effecting the kinetics. Thus, this study contributes new methodology to identify compounds that disrupt the dimerization of GPCRs in general and validates the first active compounds that disrupt the Rh dimer specifically.—Getter, T., Gulati, S., Zimmerman, R., Chen, Y., Vinberg, F., Palczewski, K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 33, 9526–9539 (2019). www.fasebj.org.

Diastereoselective α-Sulfenylation of N- tert-Butanesulfinyl Imidates

A diastereoselective α-sulfenylation of chiral α-aryl/alkyl N-tert-butanesulfinyl imidates has been developed. Suitable sulfur electrophiles can be used as sulfenylating reagents to intercept aza-enolates generated from imidate deprotonation, giving α-thiofunctionalized imidates in good yields with high diastereocontrol. This protocol for C-S bond formation can efficiently synthesize enantioenriched 1,2-sulfanyl amine derivatives such as sulconazole.

Enantio- and diastereoselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea catalysis

The enantioselective addition of thioacetic acid to nitroalkenes was achieved using N-sulfinyl urea catalysis. In this report, the scope of the reaction was extended to the enantio- and diastereoselective thioacetic acid addition to cyclic α,β-disubstitut

Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis

(Chemical Equation Presented) The highly enantioselective addition of thioacetic acid to nitroalkenes using a new sulfinyl urea organocatalyst is described. The addition of thioacetic acid proceeds in high yields and enantioselectivities for a variety of