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Bis-aminals: Efficient tools for bis-macrocycle synthesis
Le Baccon,Chuburu,Toupet,Handel,Soibinet,Dechamps-Olivier,Barbier,Aplincourt
, p. 1168 - 1174 (2001)
Tetraazamacrocyclic bis-aminals prove to be excellent tools for the synthesis of symmetrical, dissymmetrical or functionalized bis-tetraazamacrocycles. The key feature of the process is the separation of insoluble mono- or bis-quaternary ammonium salts from solution during the course of the alkylation reaction.
