613228-02-7

Upstream product

• 106-47-8 4-chloro-aniline 
• 142142-23-2 4-(4-chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol 
• 79-08-3 bromoacetic acid 
• 97528-94-4 1-(4-Methoxy-benzoyl)-4-(4-chlor-phenyl)-thiosemicarbazid 
• 701919-77-9 C₁₀H₈ClN₃S 

Relevant academic research and scientific papers

Discovery of protein-protein interaction inhibitors of replication protein A

Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein-protein interactions involving the N-terminal domain of the 70 kDa subunit with partner proteins. Inhibition of these interactions increases sensitivity toward DNA damage and replication stress and may therefore be a potential strategy for cancer drug discovery. Toward this end, we have discovered two lead series of compounds, derived from hits obtained from a fragment-based screen, that bind to RPA70N with low micromolar affinity and inhibit the binding of an ATRIP-derived peptide to RPA. These compounds may offer a promising starting point for the discovery of clinically useful RPA inhibitors.