701919-77-9

Upstream product

• 106-47-8 4-chloro-aniline 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 142142-23-2 4-(4-chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol 
• 54543-39-4 4-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 613228-02-7 C₁₇H₁₄ClN₃O₃S 
• 1436433-69-0 C₁₆H₁₁ClFN₃O₂S 
• 97528-94-4 1-(4-Methoxy-benzoyl)-4-(4-chlor-phenyl)-thiosemicarbazid 
• 54543-18-9 4-(4-chlorophenyl)-1-(4-fluorobenzoyl)-thiosemicarbazide 

Relevant academic research and scientific papers

Discovery of protein-protein interaction inhibitors of replication protein A

Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein-protein interactions involving the N-terminal domain of the 70 kDa subunit with partner proteins. Inhibition of these interactions increases sensitivity toward DNA damage and replication stress and may therefore be a potential strategy for cancer drug discovery. Toward this end, we have discovered two lead series of compounds, derived from hits obtained from a fragment-based screen, that bind to RPA70N with low micromolar affinity and inhibit the binding of an ATRIP-derived peptide to RPA. These compounds may offer a promising starting point for the discovery of clinically useful RPA inhibitors.