61323-64-6

Basic information

• Product Name: 4-(4-CHLOROPHENYL)-2(3H)-THIAZOLONE HYDRAZONE
• Synonyms: 4-(4-CHLOROPHENYL)-2(3H)-THIAZOLONE HYDRAZONE;[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazine
• CAS NO: 61323-64-6
• Molecular Formula: C₉H₈ClN₃S
• Molecular Weight: 225.7
• Mol File: 61323-64-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-CHLOROPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLOROPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(61323-64-6)
• EPA Substance Registry System: 4-(4-CHLOROPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(61323-64-6)

Safety Data

• Hazardous Substances Data: 61323-64-6(Hazardous Substances Data)

Upstream product

• 2103-96-0 2-chloro-4-(4-chlorophenyl)thiazole 
• 79-19-6 thiosemicarbazide 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 7275-22-1 1-acetylthiosemicarbazide 
• 1629144-27-9 2-phenoxy-4-(4-chlorophenyl)thiazole 
• 937-20-2 p-chlorophenacyl chloride 

Downstream Products

• 82100-80-9 2-(3',5'-dimethyl-4'-ethylpyrazol-1'yl)-4-(p-chlorophenyl)thiazole 
• 128228-97-7 2-<3-trifluoromethyl-5-(2-thienyl)pyrazol-1-yl>-4-p-chlorophenylthiazole 
• 476172-19-7 2-(5-hydroxy-3-(2-thienyl)-5-trifluoromethylpyrazolin-1-yl)-4-(4-chlorophenyl)thiazole 
• 1213776-62-5 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(5-chloro-2-hydroxyphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-63-6 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(4-chlorophenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-64-7 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(5-chloro-2-hydroxy-3-iodophenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-65-8 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-66-9 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(5-chloro-2-hydroxy-4-methylphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-67-0 C₂₆H₂₃Cl₃IN₅OS 
• 1213776-68-1 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(3-bromo-5-chloro-2-hydroxy-4-methylphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-69-2 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(4-aminophenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-70-5 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(4-methoxyphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-71-6 1-(4-(4-chlorophenyl)-2-thiazolyl)-3-(2-hydroxy-3-iodo-5-methylphenyl)-5-(2-butyl-4-chloro-1H-imidazol-5-yl)-2-pyrazoline 
• 1213776-72-7 C₂₆H₂₄BrCl₂N₅OS 

Relevant articles and documents

Chlorine-containing compound and application thereof as antifungal drug

The invention discloses a chlorine-containing compound and application thereof as an antifungal drug. The invention claims to protect a compound as shown in a formula I or pharmaceutically acceptable salts, esters and solvates thereof. In the formula I, R is -NH2 or -N=C(CH3)2. Compared with itraconazole, fluconazole and amphotericin B, the compound as shown in the formula I provided by the invention has a smaller MIC value, which shows that the compound has a more excellent antifungal effect.

Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clinical trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary end point and was abandoned. In previous work, we identified the novel IDO1 inhibitor N-(4-chlorophenyl)-2-((5-phenylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide 1 through high-throughput screening (HTS). Herein, we report a structure-activity relationship (SAR) study of this compound, which resulted in the potent IDO1 inhibitor 1-(4-cyanophenyl)-3-(3-(cyclopropylethynyl)imidazo[2,1-b]thiazol-5-yl)thiourea 47 (hIDO IC50 = 16.4 nM). X-ray cocrystal structural analysis revealed that the basis for this high potency is a unique sulfur-aromatic interaction network formed by the thiourea moiety of 47 with F163 and F226. This finding is expected to inspire new approaches toward the discovery of potent IDO1 inhibitors in the future.

Novel one-pot expeditious synthesis of 2,4-disubstituted thiazoles through a three-component reaction under solvent free conditions

An expeditious one pot method has been developed for the synthesis of 2,4-disubstituted thiazoles under solvent free conditions via a multicomponent approach. Substituted thiazoles were synthesized with high yields by the reaction of cyclic ketones, thios