128433-00-1

Basic information

• Product Name: 4-(4-chlorophenyl)-2-(1H-pyrazol-1-yl)thiazole
• Synonyms: 4-(4-chlorophenyl)-2-(1H-pyrazol-1-yl)thiazole
• CAS NO: 128433-00-1
• Molecular Weight: 261.735
• Mol File: 128433-00-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-chlorophenyl)-2-(1H-pyrazol-1-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-2-(1H-pyrazol-1-yl)thiazole(128433-00-1)
• EPA Substance Registry System: 4-(4-chlorophenyl)-2-(1H-pyrazol-1-yl)thiazole(128433-00-1)

Safety Data

• Hazardous Substances Data: 128433-00-1(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 2103-96-0 2-chloro-4-(4-chlorophenyl)thiazole 
• 61323-64-6 [4-(4-Chloro-phenyl)-thiazol-2-yl]-hydrazine 
• 102-52-3 malonaldehydebis(dimethylacetal) 

Relevant articles and documents

Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3

A series of novel 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives, 6(a-o) were designed, synthesized and evaluated for inhibitory activity against human PDE3A and PDE3B. In PDE3 assay, entire set of targeted analogs showed consid

Laccase-catalysed homocoupling of primary aromatic amines towards the biosynthesis of dyes

Coloured disubstituted benzoquinonimine trimeric structures are obtained as main reaction products of the oxidation of p-electron donor pri-mary aromatic amines using two different laccases, CotA-laccase from Baccilus subtilus and TvL from Trametes versicolor. These orange-red to purple products, presenting high molar extinction coeffi-cients, presumably result from oxidative homocou-pling reactions, through the formation of N-C bonds at positions 2 and 5, of the laccase oxidised inter-mediate as showed in the proposed oxidative path-way. The product of 1,4-phenylenediamine is shown to be the trimer known as Bandrowski's base which has an established role in hair and fur dyeing. Our results also show that the occurrence and/or rates of oxidation of aromatic amines are strongly dependent on the presence of p-electron releasing substituents in the aromatic ring and are independent on the properties of the enzyme used. Overall our data con-tribute for (i) understanding key features of laccase reactivity with p-substituted aromatic amines and (ii) establishing enzymatic processes that lead to the syn-thesis of coloured bio-products under mild condi-tions with potential impact in the cosmetic and dye industries.