613239-67-1

Basic information

• Product Name: [4-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol
• Synonyms: [4-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol
• CAS NO: 613239-67-1
• Molecular Weight: 282.262
• Mol File: 613239-67-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [4-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol(613239-67-1)
• EPA Substance Registry System: [4-(4-Trifluoromethyl-benzyloxy)-phenyl]-methanol(613239-67-1)

Safety Data

• Hazardous Substances Data: 613239-67-1(Hazardous Substances Data)

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 613239-68-2 1-(4-trifluoromethyl-benzyloxy)-4-chloromethyl-benzene 
• 613240-49-6 {5-Methyl-7-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid Methyl Ester 
• 613241-07-9 {6-methyl-8-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid methyl ester 
• 613240-81-6 {8-[4-(4-Trifluoromethyl-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic Acid Methyl Ester 
• 613240-46-3 {5-Chloro-2-methyl-4-[4-(4-trifluoromethyl-benzyloxy)-benzyl-sulfanyl]-phenoxy}-acetic Acid Methyl Ester 
• 613239-70-6 {2-Methyl-4-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester 
• 613239-69-3 {5-Methoxy-2-methyl-4-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-phenoxy}-acetic Acid Methyl Ester 
• 613240-48-5 {7-[4-(4-Trifluoromethyl-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid Methyl Ester 

Relevant articles and documents

Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) δ agonists

A series of 1,4-benzyloxybenzylsulfanylaryl carboxylic acids were prepared and their activities for PPAR receptor subtypes (α, δ, and γ) with potential indications for the treatment of dyslipidemia were investigated. Analog 13a displayed the greatest binding affinity (IC50 = 10 nM) and selectivity (120-fold) for PPARδ over PPARα. Many of the analogs investigated were found to be highly selective for PPARδ and were dependent on the point of attachment of the substituent. In the 1,4-series, analog 28e was found to be the most potent (IC50 = 1.7 nM) and selective (>1000-fold) compound for PPARδ. None of the compounds tested showed appreciable binding affinity for PPARγ.

Compounds that modulate PPAR activity and methods for their preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.