613240-41-8

Basic information

• Product Name: 1-(chloromethyl)-4-[(4-fluorophenyl)methoxy]benzene
• Synonyms: 1-(chloromethyl)-4-[(4-fluorophenyl)methoxy]benzene
• CAS NO: 613240-41-8
• Molecular Formula: C₁₄H₁₂ClFO
• Molecular Weight: 250.6958832
• Mol File: 613240-41-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(chloromethyl)-4-[(4-fluorophenyl)methoxy]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(chloromethyl)-4-[(4-fluorophenyl)methoxy]benzene(613240-41-8)
• EPA Substance Registry System: 1-(chloromethyl)-4-[(4-fluorophenyl)methoxy]benzene(613240-41-8)

Safety Data

• Hazardous Substances Data: 613240-41-8(Hazardous Substances Data)

Usage

Class

Benzene derivatives

Structure

Benzene ring
Chloromethyl group (-CH2Cl) substitution at position 1
4-[(4-fluorophenyl)methoxy] group substitution at position 4

Functional Groups

Chloromethyl (-CH2Cl)
Fluorophenyl (-C6H4-F)
Methoxy (-OCH3)

Applications

Synthesis of pharmaceuticals
Synthesis of agrochemicals

Reactivity

Versatile

Structural Properties

Valuable for creating new chemical compounds

Potential

Building block for various applications in medicine and agriculture

Industry

Chemical industry

Key Intermediate

Used in the production of fine chemicals and specialty materials

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 459-46-1 4-Fluorobenzyl bromide 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 56442-17-2 4-((4-fluorobenzyl)oxy)benzaldehyde 
• 117113-98-1 [4-(4-Fluoro-benzyloxy)-phenyl]-methanol 

Downstream Products

• 849807-02-9 (4-((4-fluorobenzyl)oxy)phenyl)methanamine 
• 613240-42-9 {4-[4-(4-Fluoro-benzyloxy)-benzylsulfanyl]-2-methyl-phenoxy}-acetic Acid Methyl Ester 

Relevant articles and documents

Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents

Taking sophoridine as a lead compound, 58 sophoridine derivatives were designed, synthesized and evaluated for their antiproliferative activity in the HepG2 cancer cell line. Among the 58 compounds, 33 compounds showed potent antiproliferative activity wi

Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents

In the present study, a series of 3-benzylquinazolin-4(3H)-ones were synthesized and characterized. Their vasodilative effects were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with 60 mM KCl. The SAR of target compounds was discussed preliminarily. Among these compounds, 2a and 2c displayed potent vasodilatation action and could compete significantly the rat mesenteric arterial rings induced contraction with phenylephrine. Compounds 2a and 2c were further tested for their antihypertensive effects in SHR by oral administration. The results indicated that 2a and 2c could reduce significantly both diastolic and systolic blood pressure. Moreover, 2c displayed antihypertensive effect in a dose dependent manner, and could maintain the effects for 6 h at a dosage of 4.0 mg/kg. These findings suggest that the title compounds are novel vasodilative agents, representing a novel series of promising antihypertensive agents.

Compounds that modulate PPAR activity and methods for their preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.