613263-26-6Relevant academic research and scientific papers
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
Romagnoli, Romeo,Baraldi, Pier Giovanni,Jung, M. Katherine,Iaconinoto, Maria Antonietta,Carrion, Maria Dora,Remusat, Vincent,Preti, Delia,Tabrizi, Mojgan Aghazadeh,Francesca, Fruttarolo,De Clercq, Erik,Balzarini, Jan,Hamel, Ernest
, p. 4048 - 4052 (2005)
A new series of compounds, in which the 2-amino-4-methoxyphenyl ring of phenstatin analogue 5 was replaced with 2- or 3-amino-benzoheterocycles, was synthesized and evaluated for antiproliferative activity and inhibition of colchicine binding. The lack of
Substituted Benzothietes: Synthesis and a Quantum Chemical Investigation of Their Cycloreversion Properties
Ahlburg, Nils L.,Velarde, Andres R.,Kieber-Emmons, Matthew T.,Jones, Peter G.,Werz, Daniel B.
supporting information, p. 4255 - 4260 (2020/06/04)
A flexible synthesis for highly substituted benzothietes that does not require flash-vacuum pyrolysis was developed. This allows for the use of a number of functional groups and nonvaporizable molecules. Highly stabilized derivatives were isolated. The molecular orbital properties of various benzothietes were evaluated by density functional methods. The mechanism of the cycloreversion of the four-membered ring was compared to that of the oxygen-containing analogues.
Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents
Romagnoli, Romeo,Baraldi, Pier Giovanni,Cara, Carlota Lopez,Hamel, Ernest,Basso, Giuseppe,Bortolozzi, Roberta,Viola, Giampietro
experimental part, p. 5781 - 5791 (2011/02/22)
The biological importance of microtubules in mitosis, as well as in interphase, makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]thiophenes are attractive as inhibitors of tubulin polymerization. T
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cara, Carlota Lopez,Preti, Delia,Fruttarolo, Francesca,Pavani, Maria Giovanna,Tabrizi, Mojgan Aghazadeh,Tolomeo, Manlio,Grimaudo, Stefania,Di Cristina, Antonella,Balzarini, Jan,Hadfield, John A.,Brancale, Andrea,Hamel, Ernest
, p. 2273 - 2277 (2008/02/02)
Two new series of inhibitors of tubulin polymerization based on the 2-amino-3-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton and its 3-amino positional isomer were synthesized and evaluated for antiproliferative activity, inhibition of tub
