613263-91-5Relevant academic research and scientific papers
Chiral monomers with minimal functional group linkages for suspension co-polymerization: A Suzuki coupling approach
Hulme, Alison N.,Barron, Sarah A.,Walker, Andrew J.
, p. 1096 - 1100 (2003)
A new strategy for the synthesis of chiral monomers for co-polymerization with styrene is described. Suzuki coupling of 4-vinylphenylboronic acid with chiral aryl triflates 5 and 13, and subsequent elaboration has resulted in chiral monomers 9 and 10. One of these monomers 10 has subsequently been incorporated into a polystyrene gel-type resin 16 with a functional group loading of 0.48 mmolg-1.
Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide
Bismuto, Alessandro,Boehm, Philip,Morandi, Bill,Roediger, Sven
, p. 17887 - 17896 (2020/08/19)
An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.
