6134-75-4Relevant academic research and scientific papers
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
Shirai, Fumiyuki,Tsumura, Takeshi,Yashiroda, Yoko,Yuki, Hitomi,Niwa, Hideaki,Sato, Shin,Chikada, Tsubasa,Koda, Yasuko,Washizuka, Kenichi,Yoshimoto, Nobuko,Abe, Masako,Onuki, Tetsuo,Mazaki, Yui,Hirama, Chizuko,Fukami, Takehiro,Watanabe, Hirofumi,Honma, Teruki,Umehara, Takashi,Shirouzu, Mikako,Okue, Masayuki,Kano, Yuko,Watanabe, Takashi,Kitamura, Kouichi,Shitara, Eiki,Muramatsu, Yukiko,Yoshida, Haruka,Mizutani, Anna,Seimiya, Hiroyuki,Yoshida, Minoru,Koyama, Hiroo
, p. 3407 - 3427 (2019/04/17)
The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of poly(ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been reported to reduce the Wnt/β-catenin signal by preventing poly ADP-ribosylation-
4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline- 3-carboxylic acid
Ukrainets,Kolesnik,Sidorenko,Gorokhova,Turov
, p. 326 - 333 (2008/09/21)
A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8- hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus.
