61342-80-1

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 60-18-4 L-tyrosine 
• 540-88-5 acetic acid tert-butyl ester 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 129460-19-1 N-(9-fluorenylmethoxycarbonyl)(O-tert-butyl)tyrosine tert-butyl ester 

Downstream Products

• 16870-43-2 L-tyrosine hydrochloride 
• 1246222-78-5 C₂₇H₄₄N₂O₅ 
• 1278457-75-2 (2S)-2-(bis-(2-(bis-(carboxymethyl)-amino)-ethyl)-amino)-3-(4-hydroxy-phenyl)-propionic acid 
• 1278457-68-3 tert-butyl (2S)-2-(bis-(2-(bis-(tert-butoxycarbonylmethyl)amino)-ethyl)-amino)-3-(4-tert-butoxy-phenyl)-propionate 
• 1140408-28-1 tert-butyl 2-(2-(5-benzyl-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate 
• 1140408-24-7 tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate 
• 1140408-14-5 tert-butyl 2-(2-(5-benzyl-6-oxo-3-phenylpyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate 
• 1147135-42-9 C₄₁H₅₈N₂O₈Si 
• 300408-92-8 N-3',4'-dihydroxybenzoyl-O-tert-butyl-L-tyrosine tert-butyl ester 
• 300408-91-7 N-p-hydroxybenzoyl-O-tert-butyl-L-tyrosine tert-butyl ester 

Relevant academic research and scientific papers

Fluorine-containing sulfonyl compound as well as intermediate, preparation method and application thereof

The invention discloses a fluorine-containing sulfonyl compound as well as an intermediate, a preparation method and application thereof. The fluorine-containing sulfonyl compound disclosed by the invention comprises positive ions and negative ions, wherein the positive ions are shown as the formula I. The fluorine-containing sulfonyl compound can react with substrates to effectively synthetize the fluorine-containing sulfonyl compound; the toxicity is low; the preparation is simple; the use is convenient; the fluorine-containing sulfonyl compound is in a solid stable state at normal temperature. In addition, the substrate applicability of the compound is extremely wide, and a phenol compound and an amine compound can be included; the fluorine-containing sulfonyl compound is a unique solidformation reagent capable of realizing the chemical conversion at present, so that important academic and application values are realized. The formula I is shown in the description.

Simple and efficient Fmoc removal in ionic liquid

A mild method for an efficient removal of the fluorenylmethoxycarbonyl (Fmoc) group in ionic liquid was developed. The combination of a weak base such as triethylamine and [Bmim][BF4] makes the entire system more efficient for the cleavage at room temperature of various amines and amino acid methyl esters in short reaction times. The procedure works well even in the case of N-Fmoc amino acids bearing acid-sensitive protecting groups and of N-alkylated amino acid methyl esters. The solvent-free condition provides a complementary method for Fmoc deprotection in solution phase peptide synthesis and modern organic synthesis.

Enantiospecific C-H Activation Using Ruthenium Nanocatalysts

The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.

An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether

A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst.

αvβ3 integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers

RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting αvβ3 integrin and featuring spacer-arms (for surface grafting), which do not disturb the biological activity, from (L) N-(3-(trifluoromethyl)benzenesulfonyl) tyrosine used as scaffold. Various Arg-mimics were fixed on the phenol function, and the ortho position was used for the coupling of OEG spacers. All peptidomimetics were active in the nM range in a binding test toward human αvβ 3 integrin (IC50 = 0.1 to 1.7 nM) and selective versus platelet integrin αIIbβ3. Selected compounds revealed excellent ability to inhibit bone cells adhesion on vitronectin. Modeling and docking studies were performed for comparing the most active RGD peptidomimetic to cilengitide, i.e., cyclo-[RGDfN(Me)V]-. Lastly, the adhesion of endothelial cells on a cultivation support grafted with RGD peptidomimetics was significantly improved. 2009 American Chemical Society.

Toward a rational design of peptide inhibitors of ribonucleotide reductase: Structure-function and modeling studies

Mammalian ribonucleotide reductase, a chemotherapeutic target, has two subunits, mR1 and mR2, and is inhibited by AcF1TLDADF7, denoted P7. P7 corresponds to the C-terminus of mR2 and competes with mR2 for binding to mR1. We report re