61343-21-3Relevant academic research and scientific papers
Synthesis, physicochemical and anticonvulsant properties of some N-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione
Obniska, Jolanta,Zejc, Alfred
, p. 383 - 390 (2007/10/03)
The synthesis and physicochemical properties of new derivatives of N-benzyl and N-phenyl amides of 2-(3 spirocyclohexanepyrrolidine-2,5-dione) acetic acid, 4-(3-spirocyclohexanepyrrolidine-2,5-dione) benzoic acid and 4-(3-spirocyclopentanepyrrolidine-2,5-dione) benzoic acid are described. N-substituted amides were prepared by condensing the obtained acids with the corresponding phenyl- or benzylamine derivatives in DMF, in the presence of the N,N-carbonyldiimidazol (CDIM) reagent at room temperature. The compounds were evaluated for anticonvulsant activity. The portion coefficients were calculated using the Prolog P module of the Pallas system. The structure of the new amides was confirmed by elemental and spectral analyses.
