61348-53-6Relevant academic research and scientific papers
Crystal structure and DNA binding properties of khellin oxime
Beyazit, Neslihan,Kaya,?enel,?zdemir, Ay?e Daut,G?lcü, Ay?egül
, p. 450 - 457 (2019)
The dried fruits of Ammi visnaga were subjected to Soxhlet extraction with water, followed by hexane and purified by column chromatography to yield Khellin (1). Oximation of 1 yielded khellin oxime (2), crystallized by slow evaporation from CH2Cl2:EtOAc (6:3), characterized by single-crystal X-ray diffraction method for the first time. The DNA binding affinities of the 1 and 2 have been appraised by examining their ability to bind to dsFSDNA with ultraviolet-visible and fluorescence spectroscopies, thermal denaturation and square wave voltammetry techniques. The binding constants of the both compounds with dsFSDNA are calculated by UV-vis measurements. The square wave voltammograms proved that both compounds bind to dsFSDNA by intercalative binding mode. Competitive studies with ethidium bromide (EB) have shown that 1 and 2 exhibit the ability to displace the DNA-bound EB indicating 1 and 2 bind to DNA with intercalation with EB for the intercalative binding site as a challenging displacement.
REACTIVITY OF CARBONYL-CONTAINING DERIVATIVES OF 1-MONO- AND 1,3-DIPHENYLPROPANES. I. KINETICS OF THE OXIMATION REACTION OF FURANOCHROMONE, DIHYDROFLAVONONE, AND CHALCONE DERIVATIVES
Levashova, I. G.,Kazarinov, N. A.,Komissarenko, N. F.,Nel'zeva, L. B.
, p. 57 - 62 (2007/10/02)
The rate constants of the oximation reaction of more than twenty compounds belonging to the 1-mono and 1,3-diphenylpropane derivatives, and their activation energies have been determined.The oximation reaction depends on the structure and position of the
