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61366-98-1

Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis-] is a complex organic compound with the chemical formula C9H16Cl2N2O2. It is a derivative of urea, featuring a cyclohexane ring with two chloroethyl groups attached to the nitrogen atoms. Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis- is primarily used in the synthesis of certain pharmaceuticals and chemical intermediates. Due to its potential reactivity and the presence of chlorine atoms, it is important to handle Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis- with care, following appropriate safety protocols.

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  • 61366-98-1 Structure

  • Basic information

    1. Product Name: Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis-
    2. Synonyms:
    3. CAS NO:61366-98-1
    4. Molecular Formula: C12H22Cl2N4O2
    5. Molecular Weight: 325.238
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 61366-98-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis-(61366-98-1)
    11. EPA Substance Registry System: Urea, N,N''-1,4-cyclohexanediylbis[N'-(2-chloroethyl)-, cis-(61366-98-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 61366-98-1(Hazardous Substances Data)

61366-98-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 61366-98-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,6 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61366-98:
(7*6)+(6*1)+(5*3)+(4*6)+(3*6)+(2*9)+(1*8)=131
131 % 10 = 1
So 61366-98-1 is a valid CAS Registry Number.

61366-98-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,1'-((1s,4s)-cyclohexane-1,4-diyl)bis(3-(2-chloroethyl)urea)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61366-98-1 SDS

61366-98-1Downstream Products

61366-98-1Relevant articles and documents

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

Johnston,McCaleb,Clayton,Frye,Krauth,Montgomery

, p. 279 - 290 (1977)

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.

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