613662-00-3

Basic information

• Product Name: Benzene, 4-fluoro-2-nitro-1-phenoxy-
• CAS NO: 613662-00-3
• Molecular Formula: C12H8FNO3
• Molecular Weight: 233.199
• Mol File: 613662-00-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 4-fluoro-2-nitro-1-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-fluoro-2-nitro-1-phenoxy-(613662-00-3)
• EPA Substance Registry System: Benzene, 4-fluoro-2-nitro-1-phenoxy-(613662-00-3)

Safety Data

• Hazardous Substances Data: 613662-00-3(Hazardous Substances Data)

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 108-95-2 phenol 

Downstream Products

• 1400637-56-0 C₂₃H₂₁F₂NO₄ 
• 932698-41-4 N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)amine 
• 1400637-70-8 C₂₁H₁₈F⁽¹⁸⁾FN₂O₃ 
• 1400637-68-4 C₂₃H₂₁F⁽¹⁸⁾FNO₄ 
• 1400637-88-8 C₂₁H₁₈BrFN₂O₃ 
• 1400637-84-4 C₂₃H₂₁BrFNO₄ 
• 1400637-62-8 C₂₁H₁₈F₂N₂O₃ 
• 1400637-95-7 C₁₉H₁₇FN₂O₂ 
• 867252-29-7 N-(5-fluoro-2-phenoxyphenyl)acetamide 
• 928637-43-8 N-(2-bromo-5-methoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide 
• 613662-01-4 5-fluoro-2-phenoxyaniline 

Relevant articles and documents

Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein - Potential novel positron emitting tomography imaging agents

A series of novel ligands based on the diaryl anilide (DAA) class of translocator protein (TSPO) ligands was synthesised and evaluated as potential positron emitting tomography (PET) ligands for imaging TPSO in vivo. Fluorine-18 labelling of the molecules was achieved using direct radiolabelling or synthon based labelling approaches. Several of the ligands prepared have promising profiles as potential TSPO PET imaging ligands and will be evaluated further as potential clinical imaging agents.

CARBON-ISOTOPE MONOXIDE LABELING OF DAA1106 AND ITS ANALOGUES TO BE USED AS TRACERS FOR A PERIPHERAL TYPE BENZODIAZEPINE BINDING SITE

A potent and selective ligand for peripheral benzodiazepine receptor (PBR), N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide or DAA1106 and eight structurally related analogues were labelled with 11C at carbonyl position of the mol

Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucidated. Currently, we presented the pharmacological profile of two high and selective PBR ligands, N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)acetamide (7-096, DAA1106) (PBR: IC50=0.28 nM) and N-(4-chloro-2-phenoxyphenyl)-N-(2- isopropoxybenzyl)acetamide (7-099, DAA1097) (PBR: IC50=0.92 nM). The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives. The aryloxyanilide derivatives, which have been derived by opening the diazepine ring of 1, are a novel class as PBR ligands and have exhibited high and selective affinity for peripheral benzodiazepine receptors (PBRs). These novel derivatives would be useful for exploring the functions of PBR. In this paper, the design, synthesis and structure-affinity relationships of aryloxyanilide derivatives are described.