6137-68-4Relevant academic research and scientific papers
Copper-catalyzed radical oxytrifluoromethylation of alkenyl oximes at ambient temperature
Li, Xi-Tao,Lv, Ling,Gu, Qiang-Shuai,Liu, Xin-Yuan
supporting information, p. 6041 - 6046 (2018/09/11)
A mild and efficient copper-catalyzed radical oxytrifluoromethylation reaction of alkenyl oximes was successfully developed. The method provides a straightforward access to a wide range of CF3-containing isoxazolines in good to excellent yields.
Enantioselective desymmetrization of cyclopropenes by hydroacylation
Phan, Diem H. T.,Kou, Kevin G. M.,Dong, Vy M.
supporting information; experimental part, p. 16354 - 16355 (2011/02/24)
We report an enantioselective desymmetrization of cyclopropenes by intermolecular Rh-catalyzed hydroacylation. Cyclopropylketones, bearing quaternary stereocenters, are produced with diastereocontrol (up to >20:1) and excellent enantiomeric excess (up to >99 ee).
Enzymatic kinetic resolution of 1-(3′-furyl)-3-buten-1-ol and 2-(2′-furyl)-propan-1-ol
Bierstedt, Anja,Stoelting, Joern,Froehlich, Roland,Metz, Peter
, p. 3399 - 3407 (2007/10/03)
The enzymatic kinetic resolution of the racemic alcohols 1-(3′-furyl)-3-buten-1-ol (±)-1 and 2-(2′-furyl)propan-1-ol (±)-2 was investigated by screening a range of lipases and esterases for enantioselective transacylation, as well as for enantioselective hydrolysis. For both alcohols, lipase-catalyzed hydrolysis of the derived racemic acetate gave the best results for accessing the desired (S)-enantiomers. In the case of the secondary alcohol (±)-1, ASL turned out to be the optimum enzyme, whereas PPL was found to be superior in the case of the primary alcohol (±)-2. Additionally, an alternative access to (S)-2 via Oppolzer's camphor sultam methodology is described.
The Stereochemistry of Rearrangements of Aryl and Hetaryl Groups to Primary Carbenic Centers
Slack, W. E.,Taylor, W.,Moseley, C. G.,Chang, K. T.,Kraska, A.,et al.
, p. 2647 - 2650 (2007/10/02)
The products and stereochemistries of carbenic decompositions of varied 2-aryl-1-diazoalkanes and 1-diazo-2-(2-hetaryl)propanes have been determined.
UNEXPECTED REGIOSELECTIVE DIELS-ALDER CYCLOADDITION REACTIONS BETWEEN 3-FLUOROBENZYNE AND 2-ALKYLFURANS
Gribble, Gordon W.,Keavy, Daniel J.,Branz, Stephen E.,Kelly, William J.,Pals, Mark A.
, p. 6227 - 6230 (2007/10/02)
The Diels-Alder reaction between 3-fluorobenzyne (1) and 2-alkylfurans (2) gives a mixture of syn adduct 3 and anti adduct 4.The syn cycloadduct invariably predominates and the regioselectivity increases in the order: R= Me Et i-Pr t-Bu, to a maximum of 90percent syn adduct 3d for 2-tert-butylfuran.These results are rationalized in terms of a concerted nonsynchronous transition state that reflects an alkyl steric effect and a polarized aryne 1.
