61388-77-0Relevant academic research and scientific papers
Microwave-assisted synthesis of 3,5-disubstituted thiohydantoins using functional ionic liquid as soluble support
Zhuo, Chen,Xian, Dong,Hui, Xie,Mei, Li
experimental part, p. 1121 - 1127 (2011/06/17)
A new approach for the syntheses of 3,5-disubstituted thiohydantoins was described using functionalized ionic liquid as soluble support. The products were obtained in good yields and purities after cyclization-cleavage from the ionic-liquid-supported under microwave irradiation, the ionic-liquid-supported species can there be purified from the reaction mixture by simple washing, and no chromatographic purification were needed during the synthesis. The Japan Institute of Heterocyclic Chemistry.
Traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on functionalized ionic-liquid support
Yao, Chao,Zhang, Yandong,Zhang, Guolin,Chen, Wenteng,Yu, Yongping,Houghten, Richard A.
scheme or table, p. 717 - 724 (2011/03/19)
A traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on a novel functionalized ionic-liquid support, 5, is described. Acylation of benzylamine functionalized ionic-liquid support with amino acids yielded ionic-liquid-supported amino acids, which reacted with isothiocyanates to afford ionic-liquid-supported thioureas. Following intramolecular cyclization cleavage from the ionic-liquid support by trifluoroacetic acid (TFA), the desired 3,5-disubstituted thiohydantoins were obtained in good yields and purities. The efficiency of this ionic-liquid-phase strategy facilitated isolation and analysis of intermediates and removal of excess reagents and by-products during the reaction process.
A New Method of Synthesis of 3-Monosubstituted-2-thiohydantoins and -Hydantoins
Ryczek, J.
, p. 2599 - 2604 (2007/10/02)
A new method of synthesis of 3-monosubstituted derivatives of 2-thiohydantoin and hydantoin in reaction of isothiocyanate or isocyanate glycin ethyl ester with primary aliphatic and aromatic amines has been described. Crude products were obtained with high yield and purity. The structure of these compounds was confirmed by spectral methods. Key words: 2-thiohydantoin, hydantoin, isothiocyanate glycin ethyl ester, isocyanate glycin ethyl ester
