61415-62-1

Upstream product

• 52483-91-7 9.10-Diphenyl-anthracendicarbonsaeure-(2.3) 
• 83687-12-1 C₃₀H₂₆O₆ 
• 61415-63-2 9,10-diphenyl-2,3-dimethoxycarbonyl anthracene 

Downstream Products

• 245122-43-4 3-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-9,10-diphenyl-anthracene-2-carboxylic acid 
• 781666-16-8 3-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-9,10-diphenyl-anthracene-2-carboxylic acid 
• 781666-15-7 9-[2-(3-Carboxy-9,10-diphenyl)anthryl]-6-hydroxy-3H-xanthen-3-one 
• 1581248-41-0 2′,4′,5′,7′-tetrafluoro-3′,6′-dihydroxy-5,10-diphenyl-3H-spiro-[anthra[2,3-c]furan-1,9′-xanthen]-3-one 

Relevant academic research and scientific papers

Aarhus sensor green: A fluorescent probe for singlet oxygen

A tetrafluoro-substituted fluorescein derivative covalently linked to a 9,10-diphenyl anthracene moiety has been synthesized, and its photophysical properties have been characterized. This compound, denoted Aarhus Sensor Green (ASG), has distinct advantages for use as a fluorescent probe for singlet molecular oxygen, O2(a1δg). In the least, ASG overcomes several limitations inherent to the use of the related commercially available product called Singlet Oxygen Sensor Green (SOSG). The functional behavior of both ASG and SOSG derives from the fact that these weakly fluorescent compounds rapidly react with singlet oxygen via a π2 + π4 cycloaddition to irreversibly yield a highly fluorescent endoperoxide. The principal advantage of ASG over SOSG is that, at physiological pH values, both ASG and the ASG endoperoxide (ASG-EP) do not themselves photosensitize the production of singlet oxygen. As such, ASG better fits the requirement of being a benign probe. Although ASG readily enters a mammalian cell (i.e., HeLa) and responds to the presence of intracellular singlet oxygen, its behavior in this arguably complicated environment requires further investigation.

Phthalocyanines and related compounds: XLI. Synthesis of 9,10-diphenylanthracene-2,3-dicarboxylic acid derivatives

Derivatives of 9,10-diphenylanthracene-2,3-dicarboxylic acid were synthesized by the Diels-Alder reaction of 1,3-diphenylisobenzofuran with adducts of furan (or silvan) and the corresponding maleic (fumaric) acid derivative or with trans-cyclohex-4-ene-1,2-dicarbonitrile, followed by aromatization. Pleiades Publishing, Inc., 2006.

Novel fluorescent probes for singlet oxygen

The first fluorescent chemical traps for 1O2 have been developed. DPAXs react specifically with 1O2 to yield the corresponding endoperoxides, DPAX-EPs (see scheme; X = H, Cl, F). DPAXs scarcely fluoresce, while DPAX-EPs are strongly fluorescent. Since the fluorescence of these probes is unaffected by H2O2, superoxide, and nitric oxide, they are useful for the selective detection of 1O2 in biological systems.