61424-52-0

Basic information

• Product Name: Phosphine oxide, [(4-bromophenyl)methyl]diphenyl-
• Synonyms: 4-bromobenzyldiphenylphosphine oxide
• CAS NO: 61424-52-0
• Molecular Formula: C19H16BrOP
• Molecular Weight: 371.213
• Mol File: 61424-52-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 469.2±28.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Phosphine oxide, [(4-bromophenyl)methyl]diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, [(4-bromophenyl)methyl]diphenyl-(61424-52-0)
• EPA Substance Registry System: Phosphine oxide, [(4-bromophenyl)methyl]diphenyl-(61424-52-0)

Safety Data

• Hazardous Substances Data: 61424-52-0(Hazardous Substances Data)

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 1079-66-9 chloro-diphenylphosphine 
• 36838-04-7 α-Oxo-phenylmethan-diphenylphosphin 
• 829-85-6 diphenylphosphane 
• 586-75-4 4-chlorobenzoyl chloride 
• 92152-55-1 S-(p-tolyl) 4-bromophenylthioate 
• 4559-70-0 Diphenylphosphine oxide 
• 873-75-6 4-bromobenzenemethanol 
• 1122-91-4 4-bromo-benzaldehyde 
• 791-28-6 Triphenylphosphine oxide 
• 19115-00-5 sodium salt of diphenyl phosphine oxide 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 2959-74-2 benzyldiphenylphosphine oxide 

Relevant articles and documents

Transition-Metal-Free and Base-Promoted Carbon-Heteroatom Bond Formation via C-N Cleavage of Benzyl Ammonium Salts

A facile and general method for constructing carbon-heteroatom (C-P, C-O, C-S, and C-N) bonds via C-N cleavage of benzyl ammonium salts under transition-metal-free conditions was reported. The combination of t-BuOK and 18-crown-6 enabled a wide range of substituted benzyl ammonium salts to couple readily with different kinds of heteroatom nucleophiles, i.e. hydrogen phosphoryl compounds, alcohols, thiols, and amines. Good functional group tolerance was demonstrated. The scale-up reaction and one-pot synthesis were also successfully performed.

Selective C-P(O) Bond Cleavage of Organophosphine Oxides by Sodium

Sodium exhibits better efficacy and selectivity than Li and K for converting Ph3P(O) to Ph2P(OM). The destiny of PhNa co-generated is disclosed. A series of alkyl halides R4X and aryl halides ArX all react with Ph2P(ONa) to produce the corresponding phosphine oxides in good to excellent yields.

Copper-catalyzed C–P cross-coupling of arylmethyl quaternary ammonium salts via C–N bond cleavage

Abstract: A ligand-free copper-catalyzed C–P cross-coupling reaction of arylmethyl quaternary ammonium salts and diarylphosphine oxides in air is developed. Arylmethyl quaternary ammonium salts with various functional groups and a variety of dialkyl- and diarylphosphine oxides afford C–P cross-coupling products with good yields. This protocol requires no inert atmosphere, no ligand, and simple operation steps. Graphic abstract: [Figure not available: see fulltext.].